男性偏头痛和不宁腿综合征。
Migraine and restless legs syndrome in men.
机构信息
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.
出版信息
Cephalalgia. 2013 Jan;33(2):130-5. doi: 10.1177/0333102412466965. Epub 2012 Nov 15.
BACKGROUND
Previous studies suggest an association between migraine and restless legs syndrome (RLS). Population-based data, however, have been limited to women. The aim of this study is to evaluate the association between migraine and RLS in a male cohort.
METHODS
We conducted a cross-sectional study among 22,926 participants in the Physicians' Health Study. Migraine and RLS information was self-reported. RLS was classified according to four minimal diagnostic criteria. Age- and multivariable-adjusted logistic regression models were calculated.
RESULTS
Of the 22,926 participants (mean age 67.8), 2816 (12.3%) reported migraine and 1717 (7.5%) RLS. Migraine was associated with an increased multivariable-adjusted odds ratio (OR) (95% confidence interval (CI)) of 1.20 (1.04-1.38) for having RLS. The association remained stable after excluding men with potential mimics of RLS and was not modified by age.
CONCLUSIONS
Results of our study indicate an association between migraine and RLS in men. The magnitude of effect is similar to what has been reported in women.
背景
既往研究提示偏头痛与不安腿综合征（RLS）之间存在关联。然而，基于人群的研究数据仅限于女性。本研究旨在评估男性人群中偏头痛与 RLS 之间的关联。
方法
我们对医师健康研究中的 22926 名参与者进行了横断面研究。偏头痛和 RLS 信息为自我报告。根据四项最低诊断标准对 RLS 进行分类。计算年龄和多变量调整后的逻辑回归模型。
结果
在 22926 名参与者（平均年龄 67.8 岁）中，2816 名（12.3%）报告偏头痛，1717 名（7.5%）报告 RLS。偏头痛与 RLS 的多变量调整后比值比（OR）（95%置信区间（CI））增加 1.20（1.04-1.38）相关。排除 RLS 潜在类似物的男性后，该关联仍然稳定，且不受年龄影响。
结论
本研究结果提示男性偏头痛与 RLS 之间存在关联。其效应大小与女性报道的相似。
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