Department of PET/CT, The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University, Shandong Province, China.
Nucl Med Commun. 2023 Jun 1;44(6):502-508. doi: 10.1097/MNM.0000000000001690. Epub 2023 Apr 10.
To assess the characteristics of fibrotic-foci-like lung adenocarcinoma on 18 F-fluorodeoxyglucose PET/computed tomography ( 18 F-FDG PET/CT) and high-resolution computed tomography (HRCT).
This was a retrospective study with 20 cases in the fibrotic-foci-like lung adenocarcinoma group; the control group was old fibrotic-foci of the lung with 20 cases. The following 18 F-FDG PET/CT and HRCT features were evaluated: the maximum standardized uptake value (SUVmax); the tumor-to-background ratios of SUVmax (TBRmax); the long-to-short diameter ratio (L/S); anatomic location; location type; internal characteristics; marginal characteristics and surrounding structures. In the fibrotic-foci-like lung adenocarcinoma group, a comparison of 18 F-FDG uptake between the metastatic group ( n = 10) and the non-metastatic group ( n = 10) was performed. Finally, the comparison of diagnostic accuracy for fibrotic-foci-like lung adenocarcinoma between 18 F-FDG PET/CT and HRCT was performed.
The SUVmax [2.6 (1.7-7.9) vs. 1.0 (0.7-1.4)], TBRmax [2.9 (2.1-9.9) vs. 1.3 (1.2- 1.7)], L/S [2.4 (1.7-3.8) vs. 4.0 (3.2-6.3)], ground-glass opacity (GGO) [13/20 (65.0%) vs. 4/20 (20.0%)], and vessel convergence [7/20 (35.0%) vs. 1/20 (5.0%)] were found to be statistically significant differences between the fibrotic-foci-like lung adenocarcinoma group and the old fibrotic-foci group ( P < 0.05). SUVmax [7.9 (4.7-8.8) vs. 1.7 (1.2-2.2)] and TBRmax [9.9 (6.5-11.0) vs. 2.1 (1.6-2.9)] were found to be statistically significant differences between the metastatic group and the non-metastatic group ( P < 0.05). 18 F-FDG PET/CT showed the higher diagnostic accuracy for fibrotic-foci-like lung adenocarcinoma than HRCT [95.0% (19/20) vs. 65.0% (13/20), P < 0.05].
The specific characteristics of fibrotic-foci-like lung adenocarcinoma on 18 F-FDG PET/CT and HRCT were high 18 F-FDG uptake, GGO, and vessel convergence, which could be distinguished from old fibrotic-foci of the lung.
评估纤维化灶样肺腺癌在 18 F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18 F-FDG PET/CT）和高分辨率计算机断层扫描（HRCT）上的特征。
这是一项回顾性研究，纤维化灶样肺腺癌组 20 例，肺陈旧性纤维化灶对照组 20 例。评估以下 18 F-FDG PET/CT 和 HRCT 特征：最大标准化摄取值（SUVmax）；SUVmax 的肿瘤与背景比值（TBRmax）；长径与短径比值（L/S）；解剖位置；位置类型；内部特征；边缘特征和周围结构。在纤维化灶样肺腺癌组中，比较转移组（n=10）和非转移组（n=10）的 18 F-FDG 摄取情况。最后，比较 18 F-FDG PET/CT 和 HRCT 对纤维化灶样肺腺癌的诊断准确性。
SUVmax[2.6（1.7-7.9）比 1.0（0.7-1.4）]、TBRmax[2.9（2.1-9.9）比 1.3（1.2-1.7）]、L/S[2.4（1.7-3.8）比 4.0（3.2-6.3）]、磨玻璃密度影（GGO）[13/20（65.0%）比 4/20（20.0%）]和血管汇聚[7/20（35.0%）比 1/20（5.0%）]在纤维化灶样肺腺癌组和陈旧性纤维化灶组之间有统计学差异（P<0.05）。SUVmax[7.9（4.7-8.8）比 1.7（1.2-2.2）]和 TBRmax[9.9（6.5-11.0）比 1.7（1.6-2.9）]在转移组和非转移组之间有统计学差异（P<0.05）。18 F-FDG PET/CT 对纤维化灶样肺腺癌的诊断准确性高于 HRCT[95.0%（19/20）比 65.0%（13/20），P<0.05]。
18 F-FDG PET/CT 和 HRCT 上纤维化灶样肺腺癌的特征性表现为 18 F-FDG 摄取高、磨玻璃密度影和血管汇聚，可与陈旧性肺纤维化灶相鉴别。
