Medical Imaging Center, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, Xinjiang, China.
The Diagnostic Radiology Department, The 964th Hospital of PLA Joint Logistic Support Force, Changchun, Jilin, China.
Medicine (Baltimore). 2024 Sep 13;103(37):e39608. doi: 10.1097/MD.0000000000039608.
The aim of this study was to explore the clinical value of high-resolution thin-layer computed tomography (CT) for the identification of early lung adenocarcinoma. Ninety patients with early lung adenocarcinoma who were diagnosed and treated in our hospital were selected as study subjects and divided into noninvasive (NIG, n = 51) and invasive (IG, n = 39) groups according to their pathological findings. Both groups underwent high-resolution target scanning. Differences in lesion size, density, and distribution between the 2 groups were compared. Intergroup differences in the CT signs were examined. A receiver-operating characteristic curve was established to calculate the diagnostic efficacy of high-resolution, thin-layer CT for early lung adenocarcinoma infiltration. The maximum diameter and density of the tumors were significantly higher in the IG than in the NIG (P < .05). The proportions of CT signs of lobulation, spicule, and vessel convergence were higher in the IG patients compared to the NIG (P < .05). High-resolution thin-layer CT for the diagnosis of lung adenocarcinoma infiltration had an AUC of 0.6702 (P < .05), a diagnostic sensitivity of 64.10%, and a diagnostic specificity of 60.78%. High-resolution thin-layer CT had certain differential diagnostic efficacy for early lung adenocarcinoma, which clearly presents various CT signs of early lung adenocarcinoma lesions.
本研究旨在探讨高分辨率薄层 CT（CT）在早期肺腺癌识别中的临床价值。选取我院收治的 90 例早期肺腺癌患者为研究对象，根据病理结果分为非侵袭组（NIG，n=51）和侵袭组（IG，n=39）。两组均行高分辨率靶扫描，比较两组间病灶大小、密度、分布的差异，观察 CT 征象的组间差异，绘制高分辨率薄层 CT 对早期肺腺癌浸润的诊断效能曲线，计算曲线下面积。IG 组的肿瘤最大直径和密度均显著高于 NIG 组（P<.05）。IG 组的分叶、毛刺、血管集束征 CT 征象比例均高于 NIG 组（P<.05）。高分辨率薄层 CT 诊断肺腺癌浸润的 AUC 为 0.6702（P<.05），诊断灵敏度为 64.10%，特异性为 60.78%。高分辨率薄层 CT 对早期肺腺癌具有一定的鉴别诊断效能，可清晰显示早期肺腺癌病灶的多种 CT 征象。
