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SLIT mutations as potential predictive biomarkers for immunotherapy in NSCLC.

作者信息

Zhou Tong, Yi Huan, Zhu Chan, Yu Yangyang, He Qianru, Xiao Mingzhe, Qi Chuang, Lu Tianyu

机构信息

Medical Oncology Department, The Fourth People's Hospital of Changzhou, Changzhou, China.

The State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co, No.699-18 Xuanwu Avenue, Nanjing, China.

出版信息

Invest New Drugs. 2023 Apr;41(2):251-253. doi: 10.1007/s10637-023-01355-6. Epub 2023 Apr 10.

DOI:10.1007/s10637-023-01355-6
PMID:37036581
Abstract
摘要

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SLIT mutations as potential predictive biomarkers for immunotherapy in NSCLC.SLIT突变作为非小细胞肺癌免疫治疗的潜在预测生物标志物。
Invest New Drugs. 2023 Apr;41(2):251-253. doi: 10.1007/s10637-023-01355-6. Epub 2023 Apr 10.
2
Relationship between the efficacy of immunotherapy and characteristics of specific tumor mutation genes in non-small cell lung cancer patients.免疫疗法的疗效与非小细胞肺癌患者特定肿瘤突变基因特征之间的关系。
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Mutation Status and Biopsy Lesion Type Determine the Immunotherapeutic Stratification in Non-Small-Cell Lung Cancer.基因突变状态和活检病变类型决定非小细胞肺癌的免疫治疗分层。
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Response to Checkpoint Inhibition in Non-Small Cell Lung Cancer with Molecular Driver Alterations.具有分子驱动改变的非小细胞肺癌的免疫检查点抑制反应。
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The role of ERBB4 mutations in the prognosis of advanced non-small cell lung cancer treated with immune checkpoint inhibitors.ERBB4 突变在免疫检查点抑制剂治疗晚期非小细胞肺癌中的预后作用。
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BRAF mutations and BRAF mutation functional class have no negative impact on the clinical outcome of advanced NSCLC and associate with susceptibility to immunotherapy.BRAF突变和BRAF突变功能类别对晚期非小细胞肺癌的临床结局没有负面影响，且与免疫治疗敏感性相关。
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Present and Emerging Biomarkers in Immunotherapy for Metastatic Non-Small Cell Lung Cancer: A Review.免疫治疗转移性非小细胞肺癌的现有和新兴生物标志物：综述。
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本文引用的文献

1
Slit/Robo Signaling Pathway in Cancer; a New Stand Point for Cancer Treatment.缝隙/罗博信号通路在癌症中的作用：癌症治疗的新观点。
Pathol Oncol Res. 2019 Oct;25(4):1285-1293. doi: 10.1007/s12253-018-00568-y. Epub 2019 Jan 4.
2
Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer.LINE-1、SLIT2、MAL 和 IGFBP7 在非小细胞肺癌中的异常甲基化。
Oncol Rep. 2013 Apr;29(4):1308-14. doi: 10.3892/or.2013.2266. Epub 2013 Jan 31.
3
The blockade of immune checkpoints in cancer immunotherapy.癌症免疫疗法中的免疫检查点阻断。
Nat Rev Cancer. 2012 Mar 22;12(4):252-64. doi: 10.1038/nrc3239.
4
Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration.癌症、肿瘤血管生成与内皮细胞迁移中的缝隙连接蛋白和Roundabout蛋白
Angiogenesis. 2008;11(1):13-21. doi: 10.1007/s10456-008-9100-x. Epub 2008 Feb 9.
5
SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers.SLIT2是果蝇Slit2基因的人类同源物，具有肿瘤抑制活性，在肺癌和乳腺癌中经常失活。
Cancer Res. 2002 Oct 15;62(20):5874-80.