Yang Lihua, Yao Simin, Fajar Anugerah, Merchant Austin, Shi Jizhe, Luo Haifeng, Qing Zhaoxia, Deng Yaocheng, Tang Xiangwei, Gong Daoxin, Zhou Xuguo
College of Resources and Environment, Hunan Agricultural University, Changsha 410128, China.
Department of Entomology, University of Kentucky, Lexington, KY 40546, USA; Research Center for Applied Zoology, National Research and Innovation Agency (BRIN), Cibinong - Bogor 16911, West Java, Indonesia.
Food Chem. 2023 Sep 1;419:135796. doi: 10.1016/j.foodchem.2023.135796. Epub 2023 Mar 6.
Albendazole is a broad-spectrum fungicide that shows great potential in controlling fungal diseases in citrus. To quantify the dissipation behavior, residue distribution, and dietary risk of albendazole in citrus, we developed an UPLC-MS/MS analysis protocol. The average recovery rate of albendazole in whole citrus and citrus pulp ranged from 74 to 105% with an RSD of 3 to 8%, and a limit of quantification of 0.01 mg kg. The degradation half-lives were 2.8-3.0 and 5.7-17.0 days in whole citrus and citrus pulp, respectively, and the final residues of albendazole were <0.059 mg kg with a risk quotient of <1. This study not only demonstrates that the dietary risk of albendazole in citrus is negligible, but also provides empirical data to establish the maximum residual limit (MRL) for the safe application of albendazole in citrus orchards to meet the requirements for food safety as well as international trade.
阿苯达唑是一种广谱杀菌剂，在控制柑橘类真菌病害方面显示出巨大潜力。为了量化阿苯达唑在柑橘中的消解行为、残留分布和膳食风险，我们开发了一种超高效液相色谱-串联质谱（UPLC-MS/MS）分析方法。阿苯达唑在全柑橘和柑橘果肉中的平均回收率为74%至105%，相对标准偏差为3%至8%，定量限为0.01 mg/kg。阿苯达唑在全柑橘和柑橘果肉中的降解半衰期分别为2.8 - 3.0天和5.7 - 17.0天，阿苯达唑的最终残留量<0.059 mg/kg，风险商<1。本研究不仅表明柑橘中阿苯达唑的膳食风险可忽略不计，还为确定阿苯达唑在柑橘果园安全施用的最大残留限量（MRL）提供了经验数据，以满足食品安全和国际贸易的要求。
