J Am Vet Med Assoc. 2023 Apr 12;261(S1):S114-S121. doi: 10.2460/javma.22.12.0586. Print 2023 Jun 1.
Skin diseases are one of the most common problems seen in veterinary practices around the world. Many patients are presented with severe and/or chronic lesions, often refractory to treatment, and collection of skin biopsies is often beneficial to obtain or confirm a diagnosis and to help guide a management plan for patients. To obtain valuable information from skin biopsies, practitioners should follow recommended guidelines based on drug withdrawal and washout period, identification, and proper collection of skin lesions, which should be at different stages of progression, as well as include a thorough clinical history and differential list. These different steps taken prior to the submission of samples will often increase the chances of a more accurate diagnosis. Practitioners should also understand it may not always be possible for pathologists to provide a definitive diagnosis, but the information provided with skin biopsies can often be used to guide an appropriate treatment plan. This review will present general guidelines and suggestions to help obtain the most diagnostic skin samples for histopathological evaluation.
皮肤病是全球兽医实践中最常见的问题之一。许多患者的病情严重和/或慢性，往往对治疗有抗性，采集皮肤活检通常有助于获得或确认诊断，并有助于为患者制定管理计划。为了从皮肤活检中获得有价值的信息，从业者应根据停药和冲洗期、识别和适当采集处于不同进展阶段的皮肤病变的建议指南进行操作，并应包括全面的临床病史和鉴别列表。在提交样本之前采取这些不同的步骤通常会增加更准确诊断的机会。从业者还应该明白，病理学家并不总是能够提供明确的诊断，但皮肤活检提供的信息通常可用于指导适当的治疗计划。这篇综述将提出一般性的指导方针和建议，以帮助获得最具诊断价值的皮肤样本进行组织病理学评估。
