Mazurkiewicz-Kwilecki I M, Baddoo P
Pharmacol Biochem Behav. 1986 Mar;24(3):513-7. doi: 10.1016/0091-3057(86)90550-2.
Chronic diazepam treatment (5 mg/kg intragastrically, twice daily for 14 days) did not influence either hypothalamic, midbrain or cortical histamine (HA) levels or histidine decarboxylase (HD) activity in male Sprague-Dawley (200-220 g) rats. However, a small but significant decrease in hypothalamic HA concentration and significantly increased HD activity was seen following diazepam withdrawal. Air blast stress induced a significant elevation in hypothalamic HA levels and HD activity in vehicle-treated controls, diazepam-treated and diazepam-withdrawn rats, but the change in HD activity was significantly greater in the last group. The latter group also displayed the greatest elevation in plasma corticosterone levels in response to stress. Hence, diazepam withdrawal in rats results in some changes in the basal hypothalamic HA regulation and may influence the hypothalamic HA and corticosterone response to stress.
慢性地西泮治疗（5毫克/千克，灌胃，每日两次，共14天）对雄性Sprague-Dawley（200-220克）大鼠的下丘脑、中脑或皮层组胺（HA）水平以及组氨酸脱羧酶（HD）活性均无影响。然而，在地西泮撤药后，下丘脑HA浓度出现了微小但显著的下降，且HD活性显著增加。空气冲击波应激在给予赋形剂处理的对照组、地西泮处理组和地西泮撤药组大鼠中均引起下丘脑HA水平和HD活性显著升高，但最后一组HD活性的变化显著更大。后一组在应激反应中血浆皮质酮水平的升高也最为明显。因此，大鼠撤用地西泮会导致下丘脑基础HA调节出现一些变化，并可能影响下丘脑HA和皮质酮对应激的反应。
