Mazurkiewicz-Kwilecki I M, Taub H
Pharmacol Biochem Behav. 1978 Oct;9(4):465-8. doi: 10.1016/0091-3057(78)90042-4.
Stress of short duration (5 min) resulted in a significant increase in plasma corticosterone level and a significant decrease in the midbrain histamine concentration in rats. Exposure to 15 min stress caused a significant elevation in the hypothalamic histamine level. Stress of longer duration (30 or 60 min) did not affect hypothalamic, cortical or midbrain histamine concentration although plasma corticosterone level remained elevated. Repeated exposures of rats of 15 min stress did not significantly alter histamine concentration of any of the brain regions studied. Plasma corticosterone concentration was only 28% of that observed in animals exposed to single 15 min stress. Present data suggest a role of brain histamine in response to stress.
短时间（5分钟）应激导致大鼠血浆皮质酮水平显著升高，中脑组胺浓度显著降低。暴露于15分钟应激导致下丘脑组胺水平显著升高。较长时间（30或60分钟）应激虽使血浆皮质酮水平仍保持升高，但不影响下丘脑、皮质或中脑的组胺浓度。对大鼠重复进行15分钟应激暴露并未显著改变所研究的任何脑区的组胺浓度。血浆皮质酮浓度仅为单次暴露于15分钟应激的动物所观察到浓度的28%。目前的数据表明脑组胺在应激反应中发挥作用。
