缺乏证据表明儿茶酚胺能机制参与L-组氨酸对小鼠行为的抗甲基苯丙胺作用。

Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse.

作者信息

Itoh Y, Oishi R, Nishibori M, Saeki K, Furuno K, Fukuda T, Araki Y

出版信息

Pharmacol Biochem Behav. 1986 Mar;24(3):571-4. doi: 10.1016/0091-3057(86)90560-5.

Abstract

The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.

摘要

研究了L-组氨酸（HIS）对小鼠甲基苯丙胺（MAMP）诱导的运动亢进及脑单胺动力学变化的影响。HIS（1000毫克/千克）完全抑制了MAMP（1毫克/千克）诱导的运动亢进。MAMP（1毫克/千克）显著提高了多巴胺水平并降低了3,4-二羟基苯乙酸水平。MAMP（5和10毫克/千克）也使去甲肾上腺素、血清素及其代谢产物的水平发生了变化。单独给予HIS不会使这些胺类和代谢产物的水平发生显著变化，也不会影响MAMP诱导的单胺动力学改变。这些结果表明，儿茶酚胺能机制不参与HIS对MAMP行为的拮抗作用。