Roney P L, Costa L G, Murphy S D
Pharmacol Biochem Behav. 1986 Mar;24(3):737-42. doi: 10.1016/0091-3057(86)90583-6.
Three organophosphate compounds, dichlorvos, parathion and diisopropylfluorophosphate were tested as an unconditioned stimulus in the conditioned taste aversion (CTA) test. All organophosphates caused a dose-dependent CTA in rats at doses which did not induce any other signs of toxicity. Experiments with dichlorvos showed that the minimum dose which caused CTA did not alter the rats' sensitivity to pain or their behavior in either an open field or an inclined plane. Cholinesterase activity was inhibited in a dose-dependent manner in brain and plasma after administration of the organophosphates and CTA was correlated with the degree of plasma cholinesterase inhibition. CTA appears to be a sensitive indicator of neurobehavioral effects of mild exposure to organophosphates which causes only 30-40% inhibition of plasma cholinesterase.
在条件性味觉厌恶（CTA）试验中，测试了三种有机磷酸酯化合物，即敌敌畏、对硫磷和二异丙基氟磷酸酯作为非条件刺激物。所有有机磷酸酯在未引起任何其他毒性迹象的剂量下，均在大鼠中引起剂量依赖性的CTA。敌敌畏实验表明，引起CTA的最小剂量不会改变大鼠对疼痛的敏感性，也不会改变它们在旷场或倾斜平面中的行为。给予有机磷酸酯后，脑和血浆中的胆碱酯酶活性呈剂量依赖性受到抑制，且CTA与血浆胆碱酯酶抑制程度相关。CTA似乎是轻度接触有机磷酸酯后神经行为效应的敏感指标，轻度接触仅导致血浆胆碱酯酶30 - 40%的抑制。
