Critical Care Nursing Student, Student Research Committee, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Internal Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Ther Apher Dial. 2023 Aug;27(4):621-628. doi: 10.1111/1744-9987.13987. Epub 2023 Apr 11.
This study aimed to compare the effect of valerian and gabapentin on restless legs syndrome (RLS) and sleep quality in HD patients.
In this cross over clinical trial study, 40 HD patients allocated into a valerian and gabapentin group. In the first phase of the study, Group A received valerian and Group B received gabapentin 1 h before bedtime for 1 month. In the second phase, the two groups' treatment regimen was swapped. After a 1-month washout period, the same process was repeated on the crossover groups.
After the first phase, the mean score of RLS was lower in the gabapentin group. But there was no statistically significant difference between the two groups in terms of sleep quality score before and after the first and second interventions.
Gabapentin is more effective than valerian in improving RLS, but both are equally effective in improving sleep quality.
本研究旨在比较缬草根和加巴喷丁对 HD 患者不安腿综合征（RLS）和睡眠质量的影响。
在这项交叉临床试验研究中，将 40 名 HD 患者分为缬草根和加巴喷丁组。在研究的第一阶段，A 组接受缬草根，B 组在睡前 1 小时服用加巴喷丁，持续 1 个月。在第二阶段，两组的治疗方案进行了交换。在 1 个月的洗脱期后，交叉组重复相同的过程。
第一阶段后，加巴喷丁组 RLS 评分的平均值较低。但在第一和第二干预前后，两组的睡眠质量评分均无统计学差异。
加巴喷丁在改善 RLS 方面比缬草根更有效，但在改善睡眠质量方面两者同样有效。
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