Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Curr Opin Struct Biol. 2023 Jun;80:102589. doi: 10.1016/j.sbi.2023.102589. Epub 2023 Apr 9.
The membrane-bound O-acyltransferase (MBOAT) superfamily catalyses the transfer of acyl chains to substrates implicated in essential cellular functions. Aberrant function of MBOATs is associated with various diseases and MBOATs are promising drug targets. There has been recent progress in structural characterisation of MBOATs, advancing our understanding of their functional mechanism. Integrating information across the MBOAT family, we characterise a common MBOAT fold and provide a blueprint for substrate and inhibitor engagement. This work provides context for the diverse substrates, mechanisms, and evolutionary relationships of protein and small-molecule MBOATs. Further work should aim to characterise MBOATs, as inherently lipid-associated proteins, within their membrane environment.
膜结合酰基转移酶（MBOAT）超家族催化酰基链向参与重要细胞功能的底物的转移。MBOAT 的功能异常与各种疾病有关，MBOAT 是有前途的药物靶点。最近在 MBOAT 的结构特征方面取得了进展，提高了我们对其功能机制的理解。通过整合 MBOAT 家族的信息，我们对常见的 MBOAT 折叠进行了描述，并为底物和抑制剂的结合提供了蓝图。这项工作为蛋白质和小分子 MBOAT 的不同底物、机制和进化关系提供了背景。进一步的工作应该旨在在其膜环境中对 MBOAT 进行表征，因为 MBOAT 是内在的与脂质相关的蛋白质。
