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Mixed chimaerism is associated with poorer long-term failure-free survival among aplastic anaemia patients receiving HLA-matched donor transplantation.

作者信息

Xu Zheng-Li, Xu Lan-Ping, Zhang Yuan-Yuan, Cheng Yi-Fei, Mo Xiao-Dong, Han Ting-Ting, Wang Feng-Rong, Yan Chen-Hua, Sun Yu-Qian, Chen Yu-Hong, Tang Fei-Fei, Han Wei, Wang Yu, Zhang Xiao-Hui, Liu Kai-Yan, Huang Xiao-Jun

机构信息

Peking University People's Hospital, Peking University Institute of Hematology, Beijing, 100044, China.

National Clinical Research Center for Hematologic Disease, Beijing, China.

出版信息

Bone Marrow Transplant. 2023 Jul;58(7):832-834. doi: 10.1038/s41409-023-01974-w. Epub 2023 Apr 11.

DOI:10.1038/s41409-023-01974-w
PMID:37041214
Abstract
摘要

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1
Mixed chimaerism is associated with poorer long-term failure-free survival among aplastic anaemia patients receiving HLA-matched donor transplantation.混合嵌合体与接受HLA匹配供体移植的再生障碍性贫血患者较差的长期无失败生存率相关。
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First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus immunosuppressive therapy.儿童重型再生障碍性贫血的一线治疗：来自匹配家族供体的骨髓移植与免疫抑制治疗对比。
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Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors.在使用 HLA 全相合同胞供者对重型再生障碍性贫血进行骨髓移植后，体内注射 Campath-1G 可使移植物抗宿主病的发生率较低，同时混合嵌合体的发生率较高。
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Cyclophosphamide conditioning in patients with severe aplastic anaemia given unrelated marrow transplantation: a phase 1-2 dose de-escalation study.接受非亲缘骨髓移植的重型再生障碍性贫血患者的环磷酰胺预处理：一项1-2期剂量递减研究
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本文引用的文献

1
The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update.中华血液学分会关于异基因造血干细胞移植适应证、预处理方案及供者选择的专家共识（2021 年版）
J Hematol Oncol. 2021 Sep 15;14(1):145. doi: 10.1186/s13045-021-01159-2.
2
Mixed chimerism after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia.异基因造血干细胞移植治疗重型再生障碍性贫血后嵌合体形成。
Hematology. 2021 Dec;26(1):435-443. doi: 10.1080/16078454.2021.1938422.
3
Allogeneic hematopoietic stem cell transplantation in aplastic anemia: current indications and transplant strategies.
再生障碍性贫血的异基因造血干细胞移植：当前的适应证及移植策略
Blood Rev. 2021 May;47:100772. doi: 10.1016/j.blre.2020.100772. Epub 2020 Oct 31.
4
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia.重型再生障碍性贫血骨髓移植时的预处理方案选择。
Blood Adv. 2019 Oct 22;3(20):3123-3131. doi: 10.1182/bloodadvances.2019000722.
5
Paediatric amendment to adult BSH Guidelines for aplastic anaemia.成人再生障碍性贫血BSH指南的儿科修订版。
Br J Haematol. 2018 Jan;180(2):201-205. doi: 10.1111/bjh.15066. Epub 2017 Dec 28.
6
Serial chimerism analyses indicate that mixed haemopoietic chimerism influences the probability of graft rejection and disease recurrence following allogeneic stem cell transplantation (SCT) for severe aplastic anaemia (SAA): indication for routine assessment of chimerism post SCT for SAA.系列嵌合体分析表明，混合造血嵌合体影响严重再生障碍性贫血（SAA）异基因干细胞移植（SCT）后移植物排斥和疾病复发的概率：SAA进行SCT后常规评估嵌合体的指征。
Br J Haematol. 2009 Mar;144(6):933-45. doi: 10.1111/j.1365-2141.2008.07533.x. Epub 2009 Jan 9.
7
Mixed hematologic chimerism after allogeneic marrow transplantation for severe aplastic anemia is associated with a higher risk of graft rejection and a lessened incidence of acute graft-versus-host disease.异基因骨髓移植治疗重型再生障碍性贫血后出现的混合血液学嵌合与较高的移植物排斥风险及较低的急性移植物抗宿主病发生率相关。
Blood. 1986 Mar;67(3):811-6.