Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Keck Medicine Family Residency Program, Los Angeles, California, USA.
Obesity (Silver Spring). 2023 May;31(5):1402-1414. doi: 10.1002/oby.23698. Epub 2023 Apr 11.
The aim of this study was to quantify the contributions of socioeconomic, psychosocial, behavioral, reproductive, and neighborhood exposures in young adulthood to Black-White differences in incident obesity.
In the Coronary Artery Risk Development in Young Adults (CARDIA) study, 4488 Black or White adults aged 18 to 30 years without obesity at baseline (1985-1986) were followed over 30 years. Sex-specific Cox proportional hazard models were used to estimate Black-White differences in incident obesity. Models were adjusted for baseline and time-updated indicators.
During follow-up, 1777 participants developed obesity. Black women were 1.87 (95% CI: 1.63-2.13) times more likely and Black men were 1.53 (95% CI: 1.32-1.77) times more likely to develop obesity than their White counterparts after adjusting for age, field center, and baseline BMI. Baseline exposures explained 43% of this difference in women and 52% in men. Time-updated exposures explained more of the racial difference in women but less for men, compared with baseline exposures.
Adjusting for these exposures accounted for a substantial but incomplete proportion of racial disparities in incident obesity. Remaining differences may be explained by incomplete capture of the most salient aspects of these exposures or potential variation in the impact of these exposures on obesity by race.
本研究旨在量化社会经济、心理社会、行为、生殖和邻里暴露因素在青年时期对黑人和白人发生肥胖的差异的贡献。
在冠状动脉风险发展在年轻人(CARDIA)研究中,4488 名年龄在 18 至 30 岁之间的黑人或白人成年人在基线时没有肥胖(1985-1986 年),随访 30 多年。使用特定于性别的 Cox 比例风险模型来估计黑人-白人之间肥胖发生率的差异。模型调整了基线和时间更新的指标。
在随访期间,1777 名参与者发生了肥胖。调整年龄、现场中心和基线 BMI 后,黑人女性发生肥胖的可能性是白人女性的 1.87 倍(95%CI:1.63-2.13),黑人男性发生肥胖的可能性是白人男性的 1.53 倍(95%CI:1.32-1.77)。基线暴露因素解释了女性差异的 43%,男性差异的 52%。与基线暴露相比,时间更新的暴露因素解释了女性中更多的种族差异,但对男性的解释较少。
调整这些暴露因素可以解释肥胖发生率方面的种族差异的相当大但不完整的部分。剩余的差异可能是由于这些暴露因素的最显著方面未被完全捕获,或者这些暴露因素对肥胖的影响因种族而异。