Fundaro' A, Molinengo L, Cassone M C, Orsetti M
Prog Neuropsychopharmacol Biol Psychiatry. 1986;10(1):41-8. doi: 10.1016/0278-5846(86)90042-4.
The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning. In the "periodic conditioning" test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg/kg/day and 10 mg/kg/day) caused no modification of the ability of the rat to adapt its behaviour to the new experimental situation. In the "reversal test" the contingency for food delivery was switched from one lever, where responses were previously reinforced to the other lever where responses had no programmed consequences. A chronic administration of mescaline (4 mg/kg/day) caused a total incapacity of the rat to switch to the lever which became reinforced in the reversal trial. A chronic administration of 9 mg/kg/day of mescaline had an excitatory effect and the number of reinforced responses in the II and III reversals exceeded the unreinforced responses in a measure greater than in the controls.
在两种操作性条件反射实验安排下，研究了长期给予三甲氧苯乙胺对大鼠行为的影响。在“周期性条件反射”试验中，强化程序从固定比率改为固定间隔程序。三甲氧苯乙胺（4毫克/千克/天和10毫克/千克/天）并未改变大鼠使其行为适应新实验情境的能力。在“反转试验”中，食物投放的偶然性从先前对反应进行强化的一个杠杆转换到对反应无预设结果的另一个杠杆。长期给予三甲氧苯乙胺（4毫克/千克/天）导致大鼠完全无法转换到在反转试验中变为强化的杠杆。长期给予9毫克/千克/天的三甲氧苯乙胺具有兴奋作用，在第二次和第三次反转中强化反应的数量超过未强化反应的程度比对照组更大。
