Fundarò A, Ricci Gamalero S, Molinengo L
Pharmacol Res Commun. 1983 Jan;15(1):71-84. doi: 10.1016/s0031-6989(83)80082-4.
A study has been made of how the chronic administration of caffeine, d-amphetamine, imipramine and diazepam affect rat behaviour in four successive trials in which the contingency for food delivery was switched from one lever where responses were previously reinforced to the other lever where responses had no programmed consequences (reversal). A complete extinction in the first reversal was obtained with diazepam 0.3 mg/kg/day. Caffeine (6 and 18 mg/kg/day) had no effect in the first reversal and damaged rat performance in the successive reversals. Imipramine (0.6 and 4 mg/kg/day) had the same effect but only in the fourth reversal. Amphetamine (0.16 and 0.7 mg/kg/day) caused a clear damage of rat performance only in the third and fourth reversals.
一项研究探讨了长期给予咖啡因、右旋苯丙胺、丙咪嗪和地西泮如何影响大鼠在四项连续试验中的行为。在这些试验中，食物递送的条件从先前强化反应的一个杠杆切换到对反应无预设结果的另一个杠杆（反转）。地西泮0.3毫克/千克/天在第一次反转中导致完全消退。咖啡因（6和18毫克/千克/天）在第一次反转中无作用，并在后续反转中损害大鼠表现。丙咪嗪（0.6和4毫克/千克/天）有相同作用，但仅在第四次反转中出现。苯丙胺（0.16和0.7毫克/千克/天）仅在第三次和第四次反转中明显损害大鼠表现。
