Herrmann T, Voigtmann L, Knorr A, Lorenz J, Johanssen U
Radiother Oncol. 1986 Feb;5(2):127-35. doi: 10.1016/s0167-8140(86)80167-0.
The dose-time relationship of radiogenic pneumopathy was studied in 68 young pigs. The right lungs of the animals were irradiated by means of a telecobalt unit. Dose distribution calculations and the preparation and execution of irradiation were chosen to largely parallel the treatment of patients. The radiation response of the lungs was quantified by chest-X-rays, functional studies and histological and biochemical investigations of the autopsy specimens. The dose which produced unambiguous signs of radiation pneumopathy in at least 50% of the individuals (ED50), was used to draw an iso-effect plot. A steep slope of the iso-effect line was found when the number of fractions was increased from 5 to 15. In contrast, the iso-effect line showed only a small slope when the influence of overall time was investigated. Significant differences between doses for early and late reactions of the lungs could not be detected. The radiogenic lung reaction in pigs is adequately described by the relation D approximately N0.32 X T0.05 and an alpha/beta value of 3.7 Gy. These results are in a good agreement with those derived for mice by other investigators. The good comparability of the biological findings obtained with pigs to man points to the application of this dose-time relation in radiotherapeutical practice.
在68只幼猪中研究了放射性肺炎的剂量-时间关系。用钴远距离治疗机对动物的右肺进行照射。剂量分布计算以及照射的准备和实施在很大程度上选择与患者的治疗方式相似。通过胸部X线、功能研究以及尸检标本的组织学和生化研究对肺的辐射反应进行量化。使用在至少50%的个体中产生明确放射性肺炎体征的剂量（ED50）绘制等效应图。当分次照射次数从5次增加到15次时，等效应线斜率陡峭。相比之下，研究总照射时间的影响时，等效应线斜率较小。未检测到肺部早期和晚期反应剂量之间的显著差异。猪的放射性肺反应可用关系式D约为N0.32×T0.05以及α/β值3.7 Gy来充分描述。这些结果与其他研究者在小鼠中得出的结果非常一致。在猪身上获得的生物学结果与人类结果具有良好的可比性，这表明该剂量-时间关系在放射治疗实践中的应用前景。
