Herrmann T, Voigtmann L, Knorr A, Lorenz J, Johannsen U, Welker K
Radiother Oncol. 1986 Sep;7(1):69-75. doi: 10.1016/s0167-8140(86)80125-6.
Irradiations of the right lung with 6.2 MeV neutrons (38 test animals) and 60Co photons (34 test animals) were made using young pigs. Twenty animals were used as controls. Five fractions were administered in an overall treatment time of 5 or 35 days. The radiogenic pneumopathy was monitored with clinical, radiological and histological investigations, and by determining the hydroxyproline content in the lung tissue. The pneumopathy in pigs given neutrons developed after a shorter latency period and followed a more rapid and serious course than that in animals given gamma rays. While after photons the extension of the overall treatment time from 5 to 35 days led to a measurable but low increase of the ED50 this was not true for neutrons. The relative biological effectiveness (RBE) for the 6.2 MeV neutrons compared with 60Co photons was 4.0 for an overall treatment time of 5 days and 4.1 for 35 days.
使用幼猪对右肺进行了6.2 MeV中子照射（38只实验动物）和60Co光子照射（34只实验动物）。20只动物用作对照。在5天或35天的总治疗时间内给予5次分割照射。通过临床、放射学和组织学检查以及测定肺组织中的羟脯氨酸含量来监测放射性肺炎。接受中子照射的猪发生的肺炎潜伏期较短，病程比接受γ射线照射的动物更快且更严重。虽然光子照射后总治疗时间从5天延长至35天导致ED50有可测量但较低的增加，但中子照射并非如此。6.2 MeV中子与60Co光子相比，总治疗时间为5天时相对生物效应（RBE）为4.0，35天时为4.1。
