Yousif Tagwa Yousif Elsayed
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Gizan, 45142, Saudi Arabia.
Department of Medical Laboratory Sciences, College of Medical Laboratory Sciences, Alneelian university, Khartoum, Sudan.
J Blood Med. 2023 Apr 5;14:253-259. doi: 10.2147/JBM.S401469. eCollection 2023.
This study aims to investigate the prevalence of inherited thrombophilia in women with recurrent pregnancy loss during the first trimester of pregnancy. The study was assessed the potential role of inherited thrombophilia in recurrent miscarriages and evaluate the consequences of this condition on the reproductive outcomes of affected women.
This study was an analytical descriptive carried out in Khartoum, Sudan. The research comprised 98 controls who had given birth twice or more without experiencing a miscarriage and 120 patients. Each patient had done more than two miscarriages especially when the pregnancy is at its beginning trimester. (APCR), and (PS) were investigated using the clotting approach. There was an assessment of biological activities of (ATIII), (PC), and (PS) for both groups using the chromogenic method.
The average age of the patients was 34, which was higher than the average age of the controls (33.5). The patient group had a much higher rate of multiple miscarriages among the women.: 35 (29.17%), 45 (37.50%), and 40 (33.33%). The incidence of PC deficiencies was determined to be 1.02% (1/98), whereas neither ATIII nor PS deficiencies were seen in the control group (0/98). APCR was more prevalent in the control group (4.10% or 4/98).
Despite contradicting evidence to the contrary in the literature, our findings imply that most miscarriages occur when pregnancy is at the first trimester when a woman is pregnant and they are all caused by thrombophilia.
本研究旨在调查妊娠早期复发性流产女性中遗传性易栓症的患病率。该研究评估了遗传性易栓症在复发性流产中的潜在作用，并评估这种情况对受影响女性生殖结局的影响。
本研究是在苏丹喀土穆进行的一项分析性描述性研究。该研究包括98名已生育两次或更多次且未经历过流产的对照组和120名患者。每位患者都经历过两次以上流产，尤其是在妊娠早期。采用凝血方法对活化部分凝血活酶时间（APCR）和蛋白S（PS）进行检测。使用发色底物法对两组的抗凝血酶III（ATIII）、蛋白C（PC）和蛋白S（PS）的生物活性进行评估。
患者的平均年龄为34岁，高于对照组的平均年龄（33.5岁）。患者组女性多次流产的发生率更高：35例（29.17%）、45例（37.50%）和40例（33.33%）。确定蛋白C缺乏的发生率为1.02%（1/98），而对照组未发现抗凝血酶III和蛋白S缺乏（0/98）。活化部分凝血活酶时间比值升高在对照组中更普遍（4.10%或4/98）。
尽管文献中有相反的证据，但我们的研究结果表明，大多数流产发生在女性怀孕的妊娠早期，且均由易栓症引起。
