CS - 1170在儿科的基础与临床检查（作者译）

[Basic and clinical examinations of CS-1170 in pediatrics (author's transl)].

Nanri S, Sunakawa K, Hara N, Yamashita N, Akita H, Hotta M, Izeki M, Morikawa Y, Osano M, Ichihashi Y

Jpn J Antibiot. 1979 Jan;32(1):18-24.

Abstract

CS-1170 was administered for the purpose of prophylaxis during cardiac catheterization in patients with heart disease, and its blood levels were measured. 2. The mean blood level (Moni-Trol I standard) after one intravenous shot of 20 mg/kg was 53.6 mcg/ml in catheterized children aged below 6 and 66.9 mcg/ml in catheterized children aged above 10 at 30 minutes, and 1.95 mcg/ml and 5.2 mcg/ml respectively at 6 hours. 3. The mean half life of the blood level was 1.09 hours in catheterized children aged below 6, 1.37 hours in catheterized children aged above 10, and 0.71 hours in infections children. 4. The urinary excretion seemed satisfactorily high although there was a great variation. 5. The clinical efficacy was 88.9%. 6. The bacteriological efficacy was 100% for E. coli, Klebsiella, Proteus mirabilis and Staphylococcus aureus and was 0% for Staphylococcus epidermidis. 7. Although GOT and GPT were elevated in one case as a side effect, they rapidly returned to normal after discontinuation of administration.

摘要

使用CS - 1170对心脏病患者在心脏导管插入术期间进行预防，并测量其血药浓度。2. 20mg/kg静脉注射一次后，6岁以下接受导管插入术儿童在30分钟时的平均血药浓度（Moni - Trol I标准）为53.6mcg/ml，10岁以上接受导管插入术儿童为66.9mcg/ml，6小时时分别为1.95mcg/ml和5.2mcg/ml。3. 6岁以下接受导管插入术儿童血药浓度的平均半衰期为1.09小时，10岁以上接受导管插入术儿童为1.37小时，感染儿童为0.71小时。4. 尽管存在很大差异，但尿排泄似乎令人满意地高。5. 临床有效率为88.9%。6. 对大肠杆菌、克雷伯菌、奇异变形杆菌和金黄色葡萄球菌的细菌学有效率为100%，对表皮葡萄球菌为0%。7. 虽然有一例出现副作用，谷草转氨酶（GOT）和谷丙转氨酶（GPT）升高，但停药后迅速恢复正常。