Department of Chemistry, Pondicherry University, Puducherry 605014, India.
Chem Commun (Camb). 2023 Apr 27;59(35):5249-5252. doi: 10.1039/d3cc00289f.
The palladium-catalyzed remote -C-H olefination of geometrically challenging substituted cinnamates using a nitrile directing group derived from 2-cyanobenzoic acid has been described. This new protocol is applicable to various olefin coupling partners and provides the corresponding -olefinated products in very good yields and with high selectivity. In addition, using this methodology, a variety of acrylates with tethered bioactive molecules, such as naphthoquinone, methyl salicylate, paracetamol, thymol, sesamol, chalcone, naproxen, cholesterol and estrone, have been coupled to produce the desired -olefinated products.
钯催化的使用 2-氰基苯甲酸衍生的腈导向基团的具有挑战性的取代肉桂酸酯的远程 -C-H 烯基化反应已经被描述。这种新的方法适用于各种烯烃偶联试剂，并以非常好的收率和高选择性得到相应的 - 烯基化产物。此外，使用该方法，可以将各种带有生物活性分子（如萘醌、水杨酸甲酯、扑热息痛、百里酚、芝麻酚、查耳酮、萘普生、胆固醇和雌酮）的丙烯酸酯偶联起来，得到所需的 - 烯基化产物。
