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高、低修复医院的初次膝关节置换术后患者的结局相似:丹麦前瞻性多中心队列研究 SPARK 的 1 年术后结果。

Patients in high- and low-revision hospitals have similar outcomes after primary knee arthroplasty: 1-year postoperative results from the Danish prospective multicenter cohort study, SPARK.

机构信息

Department of Orthopaedic Surgery, Copenhagen University Hospital Herlev and Gentofte, Gentofte Hospitalsvej 1, 2900, Hellerup, Denmark.

Department of Orthopaedic Surgery, Section for Sports Traumatology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, NV, Denmark.

出版信息

Knee Surg Sports Traumatol Arthrosc. 2023 Aug;31(8):3487-3499. doi: 10.1007/s00167-023-07390-3. Epub 2023 Apr 12.

Abstract

PURPOSE

It is well-known that revision rates after primary knee arthroplasty vary widely. However, it is uncertain whether hospital revision rates are reliable indicators of general surgical quality as defined by patients. The SPARK study compared primary knee arthroplasty surgery at three high-volume hospitals whose revision rates differed for unknown reasons.

METHODS

This prospective observational study included primary knee arthroplasty patients (total, medial/lateral unicompartmental and patellofemoral) in two low-revision hospitals (Aarhus University Hospital and Aalborg University Hospital Farsø) and one high-revision hospital (Copenhagen University Hospital Herlev-Gentofte). Patients were followed from preoperatively (2016-17) to 1-year postoperatively with patient-reported outcome measures including Oxford Knee Score (OKS), EQ-5D-5L and Copenhagen Knee ROM (range of motion) Scale. The surgical outcomes were compared across hospitals for patients with comparable grades of radiographic knee osteoarthritis and preoperative OKS. Statistical comparisons (parametric and non-parametric) included all three hospitals.

RESULTS

97% of the 1452 patients who provided baseline data (89% of those included and 56% of those operated) responded postoperatively (90% at 1 year). Hospitals' utilization of unicompartmental knee arthroplasties differed (Aarhus 49%, Aalborg 14%, and Copenhagen 22%, p < 0.001). 28 patients had revision surgery during the first year (hospital independent, p = 0.1) and were subsequently excluded. 1-year OKS (39 ± 7) was independent of hospital (p = 0.1), even when adjusted for age, sex, Body Mass Index, baseline OKS and osteoarthritis grading. 15% of patients improved less than Minimal Important Change (8 OKS) (Aarhus 19%, Aalborg 13% and Copenhagen 14%, p = 0.051 unadjusted). Patients with comparable preoperative OKS or osteoarthritis grading had similar 1-year results across hospitals (OKS and willingness to repeat surgery, p ≥ 0.087) except for the 64 patients with Kellgren-Lawrence grade-4 (Aarhus 4-6 OKS points lower). 86% of patients were satisfied, and 92% were "willing to repeat surgery", independent of hospital (p ≥ 0.1). Hospital revision rates differences diminished during the study period.

CONCLUSIONS

Patients in hospitals with a history of differing revision rates had comparable patient-reported outcomes 1 year after primary knee arthroplasty, supporting that surgical quality should not be evaluated by revision rates alone. Future studies should explore if revision rate variations may depend as much on revision thresholds and indications as on outcomes of primary surgery.

LEVEL OF EVIDENCE

Level II (Prospective cohort study).

摘要

目的

众所周知,初次膝关节置换术后的翻修率差异很大。然而,目前尚不确定医院的翻修率是否可以作为患者所定义的一般手术质量的可靠指标。SPARK 研究比较了三家高容量医院的初次膝关节置换术,这三家医院的翻修率差异不明。

方法

本前瞻性观察性研究纳入了两家低翻修率医院(奥胡斯大学医院和奥尔堡大学医院法尔索)和一家高翻修率医院(哥本哈根大学医院赫勒莱)的初次膝关节置换术患者(总病例、内侧/外侧单髁置换和髌股关节置换)。患者从术前(2016-17 年)到术后 1 年进行随访,采用牛津膝关节评分(OKS)、EQ-5D-5L 和哥本哈根膝关节活动范围(ROM)量表等患者报告的结局指标进行评估。对具有相似放射学膝关节骨关节炎分级和术前 OKS 的患者,比较各医院的手术结果。统计学比较(参数和非参数)包括了所有 3 家医院。

结果

提供基线数据的 1452 例患者中,97%(包括 89%的入组患者和 56%的手术患者)在术后(90%在术后 1 年)进行了随访。各医院单髁膝关节置换术的使用率存在差异(奥胡斯 49%,奥尔堡 14%,哥本哈根 22%,p<0.001)。在第一年有 28 例患者接受了翻修手术(医院间独立,p=0.1),随后被排除在外。1 年时 OKS(39±7)与医院无关(p=0.1),即使调整了年龄、性别、体重指数、基线 OKS 和骨关节炎分级也是如此。15%的患者改善程度低于最小重要变化(8 分 OKS)(奥胡斯 19%,奥尔堡 13%,哥本哈根 14%,p=0.051 未校正)。具有相似术前 OKS 或骨关节炎分级的患者在各医院的 1 年结果相似(OKS 和再次手术意愿,p≥0.087),但 64 例 Kellgren-Lawrence 分级为 4 级的患者除外(奥胡斯 4-6 分 OKS 较低)。86%的患者满意,92%的患者“愿意再次手术”,与医院无关(p≥0.1)。医院翻修率的差异在研究期间有所缩小。

结论

有不同翻修率历史的医院的初次膝关节置换术后 1 年的患者报告结局相似,这支持不应仅通过翻修率来评估手术质量。未来的研究应探讨翻修率的变化是否同样取决于翻修的阈值和适应证,而不仅仅是初次手术的结局。

证据水平

II 级(前瞻性队列研究)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9578/10356638/6392f7151982/167_2023_7390_Fig1_HTML.jpg

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