Stem Cell and Brain Research Institute, INSERM U1208, Bron, France; Paris Brain Institute, Institut du Cerveau, INSERM 1127, CNRS 7225 Sorbonne Université, Paris, France.
Institut de la Vision, CNRS, INSERM, Sorbonne Université, Paris, France.
Cell Rep. 2023 Apr 25;42(4):112369. doi: 10.1016/j.celrep.2023.112369. Epub 2023 Apr 11.
To better understand how the brain allows primates to perform various sets of tasks, the ability to simultaneously record neural activity at multiple spatiotemporal scales is challenging but necessary. However, the contribution of single-unit activities (SUAs) to neurovascular activity remains to be fully understood. Here, we combine functional ultrasound imaging of cerebral blood volume (CBV) and SUA recordings in visual and fronto-medial cortices of behaving macaques. We show that SUA provides a significant estimate of the neurovascular response below the typical fMRI spatial resolution of 2mm. Furthermore, our results also show that SUAs and CBV activities are statistically uncorrelated during the resting state but correlate during tasks. These results have important implications for interpreting functional imaging findings while one constructs inferences of SUA during resting state or tasks.
为了更好地理解大脑如何让灵长类动物执行各种任务，能够在多个时空尺度上同时记录神经活动是具有挑战性但必要的。然而，单单元活动（SUA）对神经血管活动的贡献仍有待充分理解。在这里，我们结合了行为猕猴的大脑血液体积（CBV）的功能超声成像和视觉及前额皮质中的 SUA 记录。我们表明，SUA 提供了一个在典型的 fMRI 空间分辨率 2mm 以下的神经血管反应的显著估计。此外，我们的结果还表明，在静息状态下，SUA 和 CBV 活动在统计学上是不相关的，但在任务期间是相关的。这些结果对在构建静息状态或任务期间的 SUA 推断时，解释功能成像结果具有重要意义。
