Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, and.
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Am J Respir Cell Mol Biol. 2023 Sep;69(3):266-280. doi: 10.1165/rcmb.2023-0057WS.
Although significant strides have been made in the understanding of pulmonary immunology, much work remains to be done to comprehensively explain coordinated immune responses in the lung. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic only served to highlight the inadequacy of current models of host-pathogen interactions and reinforced the need for current and future generations of immunologists to unravel complex biological questions. As part of that effort, the 64th Annual Thomas L. Petty Aspen Lung Conference was themed "Bridging the Gap between Innate and Adaptive Immunity in the Lung" and featured exciting work from renowned immunologists. This report summarizes the proceedings of the 2022 Aspen Lung Conference, which was convened to discuss the roles played by innate and adaptive immunity in disease pathogenesis, evaluate the interface between the innate and adaptive immune responses, assess the role of adaptive immunity in the development of autoimmunity and autoimmune lung disease, discuss lessons learned from immunologic cancer treatments and approaches, and define new paradigms to harness the immune system to prevent and treat lung diseases.
尽管人们在肺部免疫学方面取得了重大进展，但仍有许多工作需要完成，以全面解释肺部协调的免疫反应。严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 大流行只是突显了当前宿主-病原体相互作用模型的不足，并强调了当前和未来几代免疫学家需要解决复杂的生物学问题。作为这项工作的一部分，第 64 届托马斯·L·佩蒂年度阿斯彭肺脏会议的主题是“弥合肺部固有免疫与适应性免疫之间的差距”，并展示了著名免疫学家的令人兴奋的工作。本报告总结了 2022 年阿斯彭肺脏会议的会议记录，该会议的目的是讨论固有免疫和适应性免疫在疾病发病机制中的作用，评估固有免疫和适应性免疫反应之间的界面，评估适应性免疫在自身免疫和自身免疫性肺病发展中的作用，讨论从免疫肿瘤治疗和方法中吸取的经验教训，并定义利用免疫系统预防和治疗肺部疾病的新范式。
