Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA; Central District Health Department, Grand Island, NE, USA.
Virology. 2023 May;582:100-105. doi: 10.1016/j.virol.2023.04.002. Epub 2023 Apr 7.
Influenza A viruses are a diverse group of pathogens that have been responsible for millions of human and avian deaths throughout history. Here, we illustrate the transmission potential of H7N9 influenza A virus between Coturnix quail (Coturnix sp.), domestic ducks (Anas platyrhynchos domesticus), chickens (Gallus gallus domesticus), and house sparrows (Passer domesticus) co-housed in an artificial barnyard setting. In each of four replicates, individuals from a single species were infected with the virus. Quail shed virus orally and were a source of infection for both chickens and ducks. Infected chickens transmitted the virus to quail but not to ducks or house sparrows. Infected ducks transmitted to chickens, resulting in seroconversion without viral shedding. House sparrows did not shed virus sufficiently to transmit to other species. These results demonstrate that onward transmission varies by index species, and that gallinaceous birds are more likely to maintain H7N9 than ducks or passerines.
甲型流感病毒是一组多样化的病原体，在历史上导致了数百万人和禽类死亡。在这里，我们说明了 H7N9 甲型流感病毒在人工畜舍环境中共养的鹌鹑（Coturnix sp.）、家鸭（Anas platyrhynchos domesticus）、鸡（Gallus gallus domesticus）和麻雀（Passer domesticus）之间的传播潜力。在四个重复实验中，每个物种的个体都感染了该病毒。鹌鹑经口排毒，是鸡和鸭的感染源。感染鸡将病毒传播给鹌鹑，但不能传播给鸭或麻雀。感染鸭将病毒传播给鸡，导致血清转化而无病毒排出。麻雀未能排出足够的病毒以传播给其他物种。这些结果表明，继续传播因指标物种而异，而禽类比鸭或雀形目鸟类更有可能维持 H7N9。
