Bosco-Lauth Angela M, Bowen Richard A, Root J Jeffrey
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Virology. 2016 Aug;495:161-6. doi: 10.1016/j.virol.2016.04.032. Epub 2016 May 26.
Emergent H7N9 influenza A virus has caused multiple public health and financial hardships. While some epidemiological studies have recognized infected chickens as an important bridge for human infections, the generality of this observation, the minimum infectious dose, and the shedding potential of chickens have received conflicting results. We experimentally tested the ability of domestic chickens (Gallus gallus domesticus) to transmit H7N9 to co-housed chickens and to several other animal species in an experimental live animal market. Results indicated that an infected chicken failed to initiate viral shedding of H7N9 to naïve co-housed chickens. The infected chicken did, however, successfully transmit the virus to quail (Coturnix sp.) located directly below the infected chicken cage. Oral shedding by indirectly infected quail was, on average, greater than ten-fold that of directly inoculated chickens. Best management practices in live animal market systems should consider the position of quail in stacked-cage settings.
新型H7N9甲型流感病毒已造成多重公共卫生和经济困难。虽然一些流行病学研究已确认受感染的鸡是人类感染的重要桥梁，但这一观察结果的普遍性、最小感染剂量以及鸡的病毒排泄潜力却得出了相互矛盾的结果。我们通过实验测试了家鸡（Gallus gallus domesticus）在实验性活体动物市场中将H7N9传播给同笼饲养鸡及其他几种动物的能力。结果表明，一只受感染的鸡未能引发向同笼未感染鸡的H7N9病毒排泄。然而，这只受感染的鸡确实成功地将病毒传播给了位于感染鸡笼正下方的鹌鹑（Coturnix sp.）。间接感染鹌鹑的口腔病毒排泄量平均比直接接种的鸡高十倍以上。活体动物市场系统中的最佳管理措施应考虑鹌鹑在叠层笼设置中的位置。
