Strazzulla Lauren C, Cronstein Bruce N
Department of Medicine, School of Medicine, New York University , New York, NY, 10016, USA.
Divisions of Rheumatology and Translational Medicine, Department of Medicine, School of Medicine, New York University, 550 First Avenue, MSB251, New York, NY, 10016, USA.
Purinergic Signal. 2016 Dec;12(4):583-593. doi: 10.1007/s11302-016-9527-2. Epub 2016 Jul 29.
There is growing recognition that bone serves important endocrine and immunologic functions that are compromised in several disease states. While many factors are known to affect bone metabolism, recent attention has focused on investigating the role of purinergic signaling in bone formation and regulation. Adenosine is a purine nucleoside produced intracellularly and extracellularly in response to stimuli such as hypoxia and inflammation, which then interacts with P1 receptors. Numerous studies have suggested that these receptors play a pivotal role in osteoblast, osteoclast, and chondrocyte differentiation and function. This review discusses the various ways by which adenosine signaling contributes to bone and cartilage homeostasis, while incorporating potential therapeutic applications of these signaling pathways.
人们越来越认识到，骨骼具有重要的内分泌和免疫功能，而这些功能在多种疾病状态下会受到损害。虽然已知许多因素会影响骨代谢，但最近的研究重点集中在探究嘌呤能信号在骨形成和调节中的作用。腺苷是一种嘌呤核苷，在细胞内和细胞外响应缺氧和炎症等刺激而产生，然后与P1受体相互作用。大量研究表明，这些受体在成骨细胞、破骨细胞和软骨细胞的分化及功能中起关键作用。本综述讨论了腺苷信号促进骨和软骨稳态的各种方式，同时纳入了这些信号通路的潜在治疗应用。
