Gynecological Oncology Department, Metaxa Memorial Cancer Hospital of Piraeus, Athens, Greece.
Second Department of Obstetrics and Gynecology, Medical School, University of Athens "Aretaieio" Hospital, Athens, Greece.
Acta Cytol. 2023;67(5):519-527. doi: 10.1159/000530600. Epub 2023 Apr 12.
The aim of the study was to analyze the published evidence for the use of fallopian tube brush cytology for the early detection of extrauterine serous gynecological cancer.
We systematically searched the literature and, additionally, cross-checked on the bibliographies of selected articles. The inclusion criteria involved studies assessing the utility of fallopian tube brush cytology and its applications in the diagnosis, screening, or follow-up of extrauterine serous gynecological cancer.
The search strategy resulted in 21 abstracts or full-text articles, 5 of which met the inclusion criteria. The year of publication ranged from 2016 to 2022, and a total of 193 fallopian tube samples were investigated. Cytobrush, Tubebrush©, and Cytuity™ were used to obtain salpingeal samples for liquid-based cytology evaluation.
Our findings indicate that, at present, there is a lack of satisfying evidence-based data in the literature which would support the implementation of fallopian tube brush cytology as an adjunctive tool for early detection of extrauterine serous gynecological cancer. Thus, we believe that there is need for well-designed clinical studies to assess the effectiveness and diagnostic accuracy of the method as well as to validate the cytological criteria for the diagnosis and prediction of gynecological malignancies.
本研究旨在分析有关输卵管刷细胞学用于早期检测子宫外浆液性妇科癌症的已发表证据。
我们系统地搜索了文献，并交叉检查了选定文章的参考文献。纳入标准包括评估输卵管刷细胞学的效用及其在子宫外浆液性妇科癌症的诊断、筛查或随访中的应用的研究。
搜索策略产生了 21 篇摘要或全文文章，其中 5 篇符合纳入标准。出版物年份范围从 2016 年到 2022 年，总共研究了 193 个输卵管样本。使用 Cytobrush、Tubebrush©和 Cytuity™ 获得输卵管样本进行液基细胞学评估。
我们的研究结果表明，目前，文献中缺乏令人满意的基于证据的数据，无法支持将输卵管刷细胞学作为子宫外浆液性妇科癌症早期检测的辅助工具。因此，我们认为需要进行精心设计的临床研究，以评估该方法的有效性和诊断准确性，并验证细胞学标准用于诊断和预测妇科恶性肿瘤。
