Cuesta-Rubio Osmany, Monzote Lianet, Fernández-Acosta Roberto, Pardo-Andreu Gilberto Lázaro, Rastrelli Luca
Universidad Técnica de Machala, Facultad de Ciencias Químicas y de la Salud, Ave. Panamericana km 5½, 070101, Machala, Ecuador.
Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Autopista Novia del Mediodía Km 6 1/2, 11400, La Habana, Cuba.
Phytochemistry. 2023 Jun;210:113674. doi: 10.1016/j.phytochem.2023.113674. Epub 2023 Apr 10.
Nemorosone is a bicyclic polyprenylated acylphloroglucinol derivative originally isolated from Clusia spp. and it can be obtained through chemical synthesis employing different synthetic strategies. Since its discovery, it has attracted great attention both from a biological and chemical viewpoint. In the present article, we attempted to review various chemical and biological topics around nemorosone, with an emphasis on its antiproliferative activities. For this purpose, relevant data was collected from different scientific databases including Google Scholar, PubMed, Scopus and ISI Web of Knowledge. This natural compound has shown activity against several types of malignancies such as leukemia, human colorectal, pancreatic, and breast cancer because it modulates multiple molecular pathways. Nemorosone has both cytostatic and cytotoxic activity and it also seems to induce apoptosis and ferroptosis. Additionally, it has antimicrobial capabilities against Gram-positive bacteria and parasites belonging to genus Leishmania. Its promising antiproliferative pre-clinical effects deserve further attention for anticancer and anti-parasitic drug development and translation to the clinic.
降香萜醇是一种双环多异戊烯基酰基间苯三酚衍生物，最初从藤黄属植物中分离得到，可通过采用不同合成策略的化学合成方法获得。自其被发现以来，它在生物学和化学方面都引起了极大关注。在本文中，我们试图综述围绕降香萜醇的各种化学和生物学主题，重点是其抗增殖活性。为此，从包括谷歌学术、PubMed、Scopus和ISI科学网在内的不同科学数据库中收集了相关数据。这种天然化合物已显示出对多种类型恶性肿瘤的活性，如白血病、人类结直肠癌、胰腺癌和乳腺癌，因为它能调节多种分子途径。降香萜醇具有细胞生长抑制和细胞毒性活性，似乎还能诱导细胞凋亡和铁死亡。此外，它对革兰氏阳性菌和属于利什曼原虫属的寄生虫具有抗菌能力。其有前景的临床前抗增殖作用在抗癌和抗寄生虫药物开发及转化至临床方面值得进一步关注。
