Department of Parasitology, Institute of Tropical Medicine 'Pedro Kouri', Havana City, Cuba.
Phytother Res. 2011 Mar;25(3):458-62. doi: 10.1002/ptr.3401. Epub 2011 Jan 24.
Polyisoprenylated benzophenones have been isolated from plants, particularly in the Clusiaceae family, and their biological properties recently have received considerable attention from a pharmacological point of view. The aim of the study was to investigate the polyisoprenylated benzophenones, nemorosone and guttiferone A, for their antimicrobial effect against a panel of bacteria, fungi and protozoan parasites. They showed a moderate activity against the Gram-positive bacterium Staphylococcus aureus, while no activity was demonstrated against Escherichia coli and the fungi Trichophyton rubrum and Candida albicans. An interesting activity was found for Plasmodium falciparum with IC₅₀ values lower than 1 μm, while cytotoxicity on MRC-5 cells revealed CC₅₀ values of 15.5 and 12.0 μm, respectively, for nemorosone and guttiferone A.
多异戊烯基二苯甲酮已从植物中分离出来，特别是在藤黄科植物中，其生物特性最近从药理学角度受到了相当大的关注。本研究的目的是研究多异戊烯基二苯甲酮，新木姜子素和 guttiferone A，以评估其对一系列细菌、真菌和原生动物寄生虫的抗菌作用。它们对革兰氏阳性菌金黄色葡萄球菌表现出中等活性，而对大肠杆菌和真菌红色毛癣菌和白色念珠菌没有活性。有趣的是，它们对疟原虫有活性，IC₅₀值低于 1μm，而对 MRC-5 细胞的细胞毒性显示新木姜子素和 guttiferone A 的 CC₅₀值分别为 15.5 和 12.0μm。
