Computational Neuroscience Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Room 505, Block 1, Sardar Patel Road, Adyar, Chennai, Tamil Nadu, 600036, India.
Blue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, 1202, Geneva, Switzerland.
Sci Rep. 2023 Apr 12;13(1):5928. doi: 10.1038/s41598-023-32234-y.
Human cognition is characterized by a wide range of capabilities including goal-oriented selective attention, distractor suppression, decision making, response inhibition, and working memory. Much research has focused on studying these individual components of cognition in isolation, whereas in several translational applications for cognitive impairment, multiple cognitive functions are altered in a given individual. Hence it is important to study multiple cognitive abilities in the same subject or, in computational terms, model them using a single model. To this end, we propose a unified, reinforcement learning-based agent model comprising of systems for representation, memory, value computation and exploration. We successfully modeled the aforementioned cognitive tasks and show how individual performance can be mapped to model meta-parameters. This model has the potential to serve as a proxy for cognitively impaired conditions, and can be used as a clinical testbench on which therapeutic interventions can be simulated first before delivering to human subjects.
人类认知的特点是具有广泛的能力,包括目标导向的选择性注意、抑制分心、决策、反应抑制和工作记忆。许多研究都集中在孤立地研究这些认知的单个组成部分,而在认知障碍的一些转化应用中,给定个体中的多个认知功能发生改变。因此,在同一主体中研究多种认知能力,或者用单一模型来模拟它们,这一点很重要。为此,我们提出了一个统一的、基于强化学习的代理模型,它包括表示、记忆、价值计算和探索系统。我们成功地模拟了上述认知任务,并展示了如何将个体表现映射到模型的元参数上。这个模型有可能作为认知障碍的替代模型,可以作为临床测试平台,在将治疗干预措施应用于人类受试者之前,先对其进行模拟。