Laboratory of Visual Cell Differentiation and Regulation, Basic Medical College, Zhengzhou University, Zhengzhou, 450001, China.
Department of Pathophysiology, Basic Medical College, Zhengzhou University, Zhengzhou, 450001, China.
Stem Cell Res Ther. 2023 Apr 12;14(1):84. doi: 10.1186/s13287-023-03319-2.
Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular communication. Stem cell-derived EVs are considered to have the potential for regeneration, like stem cells, while simultaneously avoiding the risk of immune rejection or tumour formation. The therapeutic effect of stem cell-derived EVs has been proven in many diseases. However, the molecular mechanism of stem cell-derived EVs in retinal repair and regeneration has not been fully clarified. In this review, we described the biological characteristics of stem cell-derived EVs, summarized the current research on stem cell-derived EV treatment in retinal repair and regeneration, and discussed the potential and challenges of stem cell-derived EVs in translational medicine.
细胞外囊泡（EVs），包括微囊泡（MVs）和外泌体，在代谢调节和细胞内通讯中发挥着关键作用。干细胞来源的 EVs 被认为具有与干细胞类似的再生潜力，同时又避免了免疫排斥或肿瘤形成的风险。干细胞来源的 EVs 的治疗效果已在许多疾病中得到证实。然而，干细胞来源的 EVs 在视网膜修复和再生中的分子机制尚未完全阐明。在这篇综述中，我们描述了干细胞来源的 EVs 的生物学特性，总结了目前关于干细胞来源的 EV 治疗在视网膜修复和再生方面的研究，并讨论了干细胞来源的 EVs 在转化医学中的潜力和挑战。
