Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.
Department of Nutrition, University of California, Davis, CA 95616, USA.
Int J Mol Sci. 2023 Mar 31;24(7):6561. doi: 10.3390/ijms24076561.
Zinc is an essential micronutrient, and its deficiency is perhaps the most prevalent and least understood worldwide. Recent advances have expanded the understanding of zinc's unique chemistry and molecular roles in a vast array of critical functions. However, beyond the concept of zinc absorption, few studies have explored the molecular basis of zinc bioavailability that determines the proportion of dietary zinc utilized in zinc-dependent processes in the body. The purpose of this review is to merge the concepts of zinc molecular biology and bioavailability with a focus on the molecular determinants of zinc luminal availability, absorption, transport, and utilization.
锌是一种必需的微量元素，其缺乏可能是全球最普遍但也最不被理解的营养缺乏症之一。最近的研究进展扩展了人们对锌独特化学性质和分子作用的认识，这些作用涉及众多关键功能。然而，除了锌吸收的概念之外，很少有研究探索决定体内依赖锌的过程中膳食锌利用率的锌生物利用度的分子基础。本综述的目的是将锌分子生物学和生物利用度的概念结合起来，重点关注腔锌可用性、吸收、转运和利用的分子决定因素。
