Yu Xinbo, Huang Changwei, Liu Jiyuan, Shi Xinyu, Li Xiaodong
The First Clinical College, China Medical University, Shenyang, Liaoning Province 110122, China.
The Second Clinical College, China Medical University, Shenyang, Liaoning Province 110122, China.
Open Life Sci. 2022 Jun 20;17(1):586-598. doi: 10.1515/biol-2022-0064. eCollection 2022.
P21-activated protein kinases (PAKs) are thought to be at the center of tumor signaling pathways. As a representative member of the group II PAK family, P21-activated protein kinase 4 (PAK4) plays an important role in the development of tumors, with several biological functions such as participating in oncogenic transformation, promoting cell division, resisting aging and apoptosis, regulating cytoskeleton and adhesion, as well as suppressing antitumor immune responses. PAK4 is also crucial in biological processes, including the occurrence, proliferation, survival, migration, invasion, drug resistance, and immune escape of tumor cells. It is closely related to poor prognosis and tumor-related pathological indicators, which have significant clinical and pathological significance. Therefore, this article offers a review of the structure, activation, and biological functions of PAK4 and its clinical and pathological importance. This overview should be of assistance for future research on PAK4 and tumors and provide new ideas for tumor treatment and prognostic evaluation of patients.
p21激活蛋白激酶（PAKs）被认为处于肿瘤信号通路的核心位置。作为II组PAK家族的代表性成员，p21激活蛋白激酶4（PAK4）在肿瘤发生发展中发挥重要作用，具有参与致癌转化、促进细胞分裂、抵抗衰老和凋亡、调节细胞骨架和黏附以及抑制抗肿瘤免疫反应等多种生物学功能。PAK4在肿瘤细胞的发生、增殖、存活、迁移、侵袭、耐药及免疫逃逸等生物学过程中也至关重要。它与不良预后及肿瘤相关病理指标密切相关，具有重要的临床和病理意义。因此，本文对PAK4的结构、激活、生物学功能及其临床和病理重要性进行综述。这一概述应为未来PAK4与肿瘤的研究提供帮助，并为肿瘤治疗及患者预后评估提供新思路。
