艾滋病毒和抗逆转录病毒药物治疗导致 T 淋巴细胞线粒体功能受损。

Impaired Mitochondrial Function in T-Lymphocytes as a Result of Exposure to HIV and ART.

机构信息

Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow 125315, Russia.

Diabetes Research Center, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

出版信息

Cells. 2023 Apr 2;12(7):1072. doi: 10.3390/cells12071072.

DOI:10.3390/cells12071072

PMID:37048145

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10093108/

Abstract

Mitochondrial dysfunction is a described phenomenon for a number of chronic and infectious diseases. At the same time, the question remains open: is this condition a consequence or a cause of the progression of the disease? In this review, we consider the role of the development of mitochondrial dysfunction in the progression of HIV (human immunodeficiency viruses) infection and the onset of AIDS (acquired immunodeficiency syndrome), as well as the direct impact of HIV on mitochondria. In addition, we will touch upon such an important issue as the effect of ART (Antiretroviral Therapy) drugs on mitochondria, since ART is currently the only effective way to curb the progression of HIV in infected patients, and because the identification of potential side effects can help to more consciously approach the development of new drugs in the treatment of HIV infection.

摘要

线粒体功能障碍是许多慢性和传染病的一种已知现象。与此同时，一个问题仍然悬而未决：这种情况是疾病进展的结果还是原因？在这篇综述中，我们考虑了线粒体功能障碍在 HIV（人类免疫缺陷病毒）感染和艾滋病（获得性免疫缺陷综合征）发病中的发展作用，以及 HIV 对线粒体的直接影响。此外，我们还将涉及到一个重要问题，即抗逆转录病毒疗法（ART）药物对线粒体的影响，因为 ART 是目前抑制感染患者 HIV 进展的唯一有效方法，并且因为确定潜在的副作用可以帮助更有意识地开发新的 HIV 感染治疗药物。