Rossi Roberta, Benetti Stefania, Lauria Barbara, Grasso Giulia, Castagno Emanuele, Ricceri Fulvio, Bondone Claudia, Versace Antonia
Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children's Hospital, A.O.U. Città della Salute e della Scienza di Torino, Piazza Polonia 94, 10126 Turin, Italy.
Department of Pediatrics, Ospedale degli Infermi, ASL TO3, Via Rivalta 29, 10098 Rivoli, Italy.
J Clin Med. 2023 Mar 29;12(7):2582. doi: 10.3390/jcm12072582.
Migraine is one of the most frequent primary headaches in childhood. The role of thrombotic predisposition in its pathogenesis is debated. Our aim was to analyse the cardiovascular risk factors and family history of major thrombotic events in children with migraine.
A retrospective, single-centre study was performed over 12 years. Our headache centre record database was screened for migraine with aura (MA) and migraine without aura (MO) on the basis of the ICHD-II (until 2013) and III criteria. A control group of otherwise healthy children was recruited. Descriptive and multivariate analyses are provided; significance was set at < 0.05.
Migraine was diagnosed in 930 children (24.7% MA); 73.3% were 9-14 years old. Children with MA were older ( < 0.001). A family history of cerebral ischemic events at ≤50 years old was more commonly reported by children with MA than those with MO ( < 0.001) and those in the control group ( = 0.001). Children with MA showed a higher risk of a family history of cerebral ischemic events at ≤50 years old than children with MO (OR: 2.6) and those in the control group (OR: 3.1). When comparing the family history of DVT, we observed a significantly increased risk for MA vs. MO (OR: 2.9).
A family history of cerebral ischemic events at ≤50 years old leads to an increased risk of MA. Further studies are needed to explore such an association.
偏头痛是儿童期最常见的原发性头痛之一。血栓形成易感性在其发病机制中的作用存在争议。我们的目的是分析偏头痛儿童的心血管危险因素和重大血栓形成事件的家族史。
进行了一项为期12年的回顾性单中心研究。根据国际头痛疾病分类第二版（ICHD-II，截至2013年）和第三版标准，在我们的头痛中心记录数据库中筛查有先兆偏头痛（MA）和无先兆偏头痛（MO）。招募了一组健康儿童作为对照组。提供了描述性和多变量分析；显著性设定为<0.05。
930名儿童被诊断为偏头痛（24.7%为MA）；73.3%的儿童年龄在9至14岁之间。MA患儿年龄较大（<0.001）。MA患儿比MO患儿（<0.001）和对照组患儿（=0.001）更常报告50岁及以下的脑缺血事件家族史。MA患儿50岁及以下脑缺血事件家族史的风险高于MO患儿（OR：2.6）和对照组患儿（OR：3.1）。在比较深静脉血栓形成的家族史时，我们观察到MA患儿与MO患儿相比风险显著增加（OR：2.9）。
50岁及以下的脑缺血事件家族史会增加患MA的风险。需要进一步研究来探索这种关联。
