受体手术台上时间对脑死亡供肾移植结局的影响：一项单中心前瞻性队列研究

The Effect of Recipient Back-Table Duration on Graft Outcome of Deceased Donor Kidneys: A Single-Center Prospective Cohort Study.

作者信息

Slagter Julia S, Rijkse Elsaline, De Wilde Roeland F, Haen Roel, Lepiesza Agnieszka, Cappelle Marie L, Kimenai Diederik H J A N, Minnee Robert C

机构信息

Division of HPB and Transplant Surgery, Department of Surgery, Erasmus MC Transplant Institute, 3015 CN Rotterdam, The Netherlands.

出版信息

J Clin Med. 2023 Apr 2;12(7):2647. doi: 10.3390/jcm12072647.

DOI:10.3390/jcm12072647

PMID:37048729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10094751/

Abstract

BACKGROUND

Little is known about the influence of the duration of the kidney back-table preparation period and kidney temperature on graft outcomes after transplantation. The aim of this study is to investigate the back-table duration and its relation to graft outcome and the relation between kidney temperature and graft outcome.

METHODS

In this prospective cohort study, deceased donor kidney temperature is measured at fixed time points using an infrared thermometer during back-table preparation and transplantation. Additionally, the back-table duration is measured using a timer.

RESULTS

Between September 2020 and July 2021, 49 kidneys were prospectively included in this study. Median back-table duration was 33.7 (standard deviation ± 14.1) min and donor kidney temperature increased up to 14.9 °C (±2.8) after 60 min of back-table preparation. Mean implantation time was 24.9 (±7.6) min and kidney temperature increased up to 25.9 °C (±2.4) after 30 min of implantation time. Longer back-table duration was significantly associated with higher rates of delayed graft function ( = 0.037). However, this observation did not sustain at 3 and 6-months post-transplantation. No association was found between kidney temperature and graft outcomes.

CONCLUSION

Longer back-table duration is significantly associated with DGF after deceased donor kidney transplantation. No association was observed between kidney temperature and graft outcomes of deceased donor kidneys.

摘要

背景

关于肾后台准备时间的长短以及肾温度对移植后移植物结局的影响，目前所知甚少。本研究的目的是调查后台准备时间及其与移植物结局的关系，以及肾温度与移植物结局的关系。

方法

在这项前瞻性队列研究中，在后台准备和移植期间，使用红外温度计在固定时间点测量死亡供体肾脏的温度。此外，使用定时器测量后台准备时间。

结果

在2020年9月至2021年7月期间，本研究前瞻性纳入了49个肾脏。后台准备的中位时间为33.7（标准差±14.1）分钟，后台准备60分钟后供体肾脏温度升高至14.9°C（±2.8）。平均植入时间为24.9（±7.6）分钟，植入30分钟后肾脏温度升高至25.9°C（±2.4）。后台准备时间越长，移植肾功能延迟发生率越高（ = 0.037）。然而，这一观察结果在移植后3个月和6个月时并未持续。未发现肾温度与移植物结局之间存在关联。