Gao Yang, Li Tan, Meng Fanshu, Hou Zhenzhong, Xu Chao, Yang Laixia
School of Mechanical Engineering, Xi'an University of Science and Technology, Xi'an 710054, China.
State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Materials (Basel). 2023 Mar 28;16(7):2687. doi: 10.3390/ma16072687.
Personalised controlled drug delivery systems (CDDSs) can adjust drug concentration levels according to patient needs, which has enormous research prospects in precision medicine. In this study, the topological optimisation method was utilised in the structural design of a hydrogel CDDS to achieve a parameter-based adjustment of the drug average concentration in the hydrogel. A polyacrylamide/sodium alginate dual-network hydrogel was selected as a drug carrier, and tetracycline hydrochloride was used as a model drug. The topological optimisation model of the hydrogel CDDS was developed. The effects of the mesh size, target concentration, and volume factor on the optimised results were investigated. Hydrogel flow channel structures were obtained, which satisfied the different target concentrations. To verify the rationality of the optimisation model, in vitro drug release experiments were carried out. The results show that the hydrogel CDDS can control drug release within 7 days, and the drug release tends to follow zero-order release behaviour. The adjustable average concentration of tetracycline hydrochloride in hydrogel CDDS is recommended in the range of 20.79 to 31.04 mol/m. This novel method provides a reference for personalised structure design of CDDS in the context of precision medicine.
个性化控释给药系统（CDDSs）能够根据患者需求调整药物浓度水平，在精准医学领域具有巨大的研究前景。本研究将拓扑优化方法应用于水凝胶CDDS的结构设计，以实现基于参数的水凝胶中药物平均浓度调节。选用聚丙烯酰胺/海藻酸钠双网络水凝胶作为药物载体，以盐酸四环素作为模型药物。建立了水凝胶CDDS的拓扑优化模型。研究了网格尺寸、目标浓度和体积因子对优化结果的影响。获得了满足不同目标浓度的水凝胶流道结构。为验证优化模型的合理性，进行了体外药物释放实验。结果表明，水凝胶CDDS可在7天内控制药物释放，且药物释放趋于符合零级释放行为。建议水凝胶CDDS中盐酸四环素的可调节平均浓度范围为20.79至31.04 mol/m。这种新方法为精准医学背景下CDDS的个性化结构设计提供了参考。
