Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA.
Adv Drug Deliv Rev. 2021 Dec;179:113997. doi: 10.1016/j.addr.2021.113997. Epub 2021 Oct 8.
The recent advancement and prevalence of wearable technologies and their ability to make digital measurements of vital signs and wellness parameters have triggered a new paradigm in the management of diseases. Drug delivery as a function of stimuli or response from wearable, closed-loop systems can offer real-time on-demand or preprogrammed drug delivery capability and offer total management of disease states. Here we review the key opportunities in this space for development of closed-loop systems, given the advent of digital wearable technologies. Particular considerations and focus are given to closed-loop systems combined with transdermal drug delivery technologies.
可穿戴技术的最新进展和普及，以及它们对生命体征和健康参数进行数字测量的能力，引发了疾病管理的新模式。作为可穿戴、闭环系统对刺激或响应的功能，药物输送可以提供实时按需或预编程的药物输送能力，并实现对疾病状态的全面管理。有鉴于数字可穿戴技术的出现，本文在该领域中为开发闭环系统审查了关键机会。特别考虑并关注了与透皮药物输送技术相结合的闭环系统。
