Large S R, Shneerson J M, Stovin P G, Wallwork J
Thorax. 1986 Jan;41(1):51-4. doi: 10.1136/thx.41.1.51.
Fifty five patients underwent thymic surgery at Papworth Hospital from April 1964 to March 1984. The number presenting and the percentage with symptoms annually remained unchanged during this period. Forty four of these 55 patients had tumours. Twenty eight had thymomas (18% of whom had myasthenia gravis and 7% red cell aplasia), nine Hodgkin's disease, four germ cell tumours, and three secondary carcinomatous tumours. Five tumours were cystic. Six further patients had non-tumourous cystic lesions (four simple, one foregut, one lymphangiectatic). The remaining five patients had follicular hyperplasia; all of these had myasthenia gravis. Complete excision was performed in 41 of the 55 patients. So far survival is 100% in those with benign lesions other than benign thymomas, where the survival was 70% at five years. Those with malignant thymomas had a 60% survival rate at five years and those with Hodgkin's disease 29%.
1964年4月至1984年3月期间，55例患者在帕普沃思医院接受了胸腺手术。在此期间，每年出现症状的患者数量和百分比保持不变。这55例患者中有44例患有肿瘤。其中28例为胸腺瘤（18%伴有重症肌无力，7%伴有红细胞再生障碍），9例为霍奇金病，4例为生殖细胞肿瘤，3例为继发性癌性肿瘤。5例肿瘤为囊性。另外6例患者有非肿瘤性囊性病变（4例单纯性，1例前肠性，1例淋巴管扩张性）。其余5例患者有滤泡性增生；所有这些患者都患有重症肌无力。55例患者中有41例进行了完整切除。到目前为止，除良性胸腺瘤外，良性病变患者的生存率为100%，良性胸腺瘤患者的五年生存率为70%。恶性胸腺瘤患者的五年生存率为60%，霍奇金病患者的五年生存率为29%。
