高甘油三酯血症时体外血小板聚集增加。

Increased in vitro platelet aggregation in hypertriglyceridemias.

作者信息

Riess H, Merk W, Falkner C, Hiller E

出版信息

Thromb Res. 1986 Feb 1;41(3):281-9. doi: 10.1016/0049-3848(86)90238-0.

Abstract

Platelet aggregation induced by ADP and collagen was monitored in 25 patients with increased serum levels of triglycerides (7 HLPs type IIb, 14 type IV, 4 type V patients) and compared with a group of 10 normolipidaemic control persons. Platelet aggregation was studied simultaneously in platelet rich plasma (PRP) by both turbidometric and impedance technique and also in whole blood (WB) by the impedance method. Whereas platelet aggregation testing by turbidometry was limited by the optical density of the plasma samples in hypertriglyceridemia, the aggregation process could easily be registered in PRP and WB using the impedance method. Threshold aggregatory concentrations with both agonists were significantly lower for all three groups of HLP.

摘要

对25例甘油三酯水平升高的患者（7例IIb型高脂蛋白血症、14例IV型、4例V型患者）进行了由二磷酸腺苷（ADP）和胶原蛋白诱导的血小板聚集监测，并与10名血脂正常的对照者组成的小组进行了比较。通过比浊法和阻抗技术同时在富血小板血浆（PRP）中研究血小板聚集，还通过阻抗法在全血（WB）中进行研究。虽然在高甘油三酯血症中，通过比浊法进行血小板聚集检测受到血浆样本光密度的限制，但使用阻抗法可以很容易地在PRP和WB中记录聚集过程。所有三组高脂蛋白血症患者对两种激动剂的阈值聚集浓度均显著较低。