Lee Won, Rho Nark-Kyoung, Yang Eun-Jung
Yonsei E1 Plastic Surgery Clinic, Anyang 14072, Republic of Korea.
Department of Dermatology, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.
Polymers (Basel). 2023 Mar 26;15(7):1649. doi: 10.3390/polym15071649.
Although hyaluronic acid (HA) filler injections are associated with various non-vascular inflammatory complications, the underlying mode of action remains unclear. The hyaluronic acid filler may not be sufficiently pure, leading to an immune response. The present study attempted to identify any impurities in hyaluronic acid fillers available on the market. Particles were counted after degrading hyaluronic acid filler with hyaluronidase. Particulate matter was subsequently observed using scanning electron microscopy, and the particle components were evaluated using energy-dispersive X-ray spectroscopy. Different quantities of impurity particles (>10 and 25 μm) were detected microscopically. Silicon and aluminum isotopes were also detected. Hyaluronic acid fillers were contaminated with these particles. The degree of contamination varied substantially among the tested filler products. These contaminant particles may evoke reactions in the patient's body. Clinicians should be aware of this source of possible contamination and its effects.
尽管透明质酸（HA）填充剂注射会引发各种非血管性炎症并发症，但其潜在作用方式仍不清楚。透明质酸填充剂可能纯度不够，从而引发免疫反应。本研究试图鉴定市售透明质酸填充剂中的任何杂质。用透明质酸酶降解透明质酸填充剂后对颗粒进行计数。随后使用扫描电子显微镜观察颗粒物，并使用能量色散X射线光谱法评估颗粒成分。在显微镜下检测到不同数量的杂质颗粒（>10和25μm）。还检测到硅和铝的同位素。透明质酸填充剂被这些颗粒污染。受试填充剂产品之间的污染程度差异很大。这些污染颗粒可能会在患者体内引发反应。临床医生应意识到这种可能的污染源及其影响。
