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使用透明质酸混合复合物治疗面部上三分之一皱纹：病例报告

Use of Hyaluronic Acid Hybrid Complex to Treat Wrinkles in the Upper Third of the Face: A Case Report.

作者信息

Dziabas Daniel C, Kasai Matheus, Chicone Gisele

机构信息

Dermatology, Dziabas Academy & Research Institute, São Paulo, BRA.

出版信息

Cureus. 2024 Nov 11;16(11):e73451. doi: 10.7759/cureus.73451. eCollection 2024 Nov.

DOI:10.7759/cureus.73451
PMID:39664133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11633721/
Abstract

Physical changes, such as skin atrophy, loss of elasticity, and the appearance of fine lines and wrinkles, are common during aging. A hybrid hyaluronic acid (HA) complex containing both low and high molecular weight has shown promising results in promoting skin restructuring by remodeling the epidermis, dermis, and hypodermis. This study describes three cases of facial aging, each with unique challenges. The upper third of the face was treated with two sessions spaced 30 days apart of hybrid HA using the blanching technique. These cases highlight the pressing need for alternative treatments that regenerate new tissues and cells, leading to a new skin architecture, as the use of neuromodulators in isolation can lead to unwanted side effects. The recovery of extracellular matrix proteins in this region with hybrid HA has significantly improved the elasticity, firmness, texture, and hydration of the skin, providing a healthier appearance and reducing the quantity and depth of facial wrinkles.

摘要

身体变化，如皮肤萎缩、弹性丧失以及细纹和皱纹的出现，在衰老过程中很常见。一种含有低分子量和高分子量的混合透明质酸（HA）复合物在通过重塑表皮、真皮和皮下组织促进皮肤重塑方面已显示出有前景的结果。本研究描述了三例面部衰老病例，每例都有独特的挑战。面部上三分之一区域采用变白技术，间隔30天进行两次混合HA治疗。这些病例凸显了对能够再生新组织和细胞、从而形成新皮肤结构的替代治疗的迫切需求，因为单独使用神经调节剂可能会导致不良副作用。混合HA使该区域细胞外基质蛋白的恢复显著改善了皮肤的弹性、紧致度、质地和水合作用，使皮肤外观更健康，减少了面部皱纹的数量和深度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/f3920e0481d9/cureus-0016-00000073451-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/b9f6fe4286d8/cureus-0016-00000073451-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/50e0831d776e/cureus-0016-00000073451-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/1dc02a3ce35c/cureus-0016-00000073451-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/984f3795a2f0/cureus-0016-00000073451-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/4648c983b1c9/cureus-0016-00000073451-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/f17414901f8a/cureus-0016-00000073451-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/f3920e0481d9/cureus-0016-00000073451-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/b9f6fe4286d8/cureus-0016-00000073451-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/50e0831d776e/cureus-0016-00000073451-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/1dc02a3ce35c/cureus-0016-00000073451-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/984f3795a2f0/cureus-0016-00000073451-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/4648c983b1c9/cureus-0016-00000073451-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/f17414901f8a/cureus-0016-00000073451-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcce/11633721/f3920e0481d9/cureus-0016-00000073451-i07.jpg

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本文引用的文献

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Determination of Hyaluronic Acid Dermal Filler Impurities Using SEM/EDS Analysis.使用扫描电子显微镜/能谱分析（SEM/EDS）测定透明质酸真皮填充剂中的杂质
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