Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France.
Aix Marseille Univ, CNRS, CINaM, Marseille, France.
Sensors (Basel). 2023 Mar 24;23(7):3434. doi: 10.3390/s23073434.
Hepatic steatosis may be caused by type 2 diabetes or obesity and is one of the origins of chronic liver disease. A non-invasive technique based on microwave propagation can be a good solution to monitor hepatic tissue pathologies. The present work is devoted to the dielectric permittivity measurements in healthy and fatty liver in the microwave range. A mouse model following normal and high sugar/glucose (HFS) diets was used. We demonstrated the change in the triglyceride and glucose concentration in the hepatic tissue of HFS diet mice. The difference in the dielectric permittivity of healthy and fatty liver was observed in the range from 100 MHz to 2 GHz. The dielectric permittivity was found to be 42 in the healthy tissue and 31 in the fatty liver tissue at 1 GHz. The obtained results demonstrate that dielectric permittivity can be a sensitive tool to distinguish between healthy and fatty hepatic tissue.
肝脂肪变性可能由 2 型糖尿病或肥胖引起，是慢性肝病的起源之一。一种基于微波传播的非侵入性技术可能是监测肝组织病变的好方法。本工作致力于在微波范围内测量健康和脂肪肝的介电常数。使用了遵循正常和高糖/葡萄糖（HFS）饮食的小鼠模型。我们证明了 HFS 饮食小鼠肝组织中甘油三酯和葡萄糖浓度的变化。在 100MHz 至 2GHz 的范围内观察到健康和脂肪肝的介电常数差异。在 1GHz 时，健康组织的介电常数为 42，脂肪肝组织的介电常数为 31。所获得的结果表明，介电常数可以成为区分健康和脂肪肝组织的敏感工具。
