Hoskins B, Fernando J C, Dulaney M D, Lim D K, Liu D D, Watanabe H K, Ho I K
Toxicol Lett. 1986 Feb;30(2):121-9. doi: 10.1016/0378-4274(86)90094-9.
Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutaneous (s.c.) injection of Soman, the intensities of toxic signs were significantly correlated with the degree of striatal AChE inhibition. In the case of Sarin, the corresponding r-values were not significant except for tremors. For Tabun-induced chewing, tremor and hind-limb abduction, the r-values were significant. The neurotoxicity was most intense between 15 min to 2 h after treatment, but at 2 or 6 h, the r-values were well below 0.5. The inhibition of brain AChE was maximal by 30 min and was still high at 24 h.
监测大鼠在50 - 85%半数致死剂量（LD50）下，由乙酰胆碱酯酶（AChE）诱导的咀嚼运动、震颤、惊厥和后肢外展情况，以确定这些不同体征的严重程度是否与脑AChE水平相关以及这种关系的时间进程。皮下注射梭曼30分钟后，中毒体征的强度与纹状体AChE抑制程度显著相关。对于沙林，除震颤外，相应的r值不显著。对于塔崩诱导的咀嚼、震颤和后肢外展，r值显著。神经毒性在治疗后15分钟至2小时最为强烈，但在2或6小时时，r值远低于0.5。脑AChE的抑制在30分钟时达到最大，24小时时仍处于较高水平。
