Departments of Diagnostic Pathology, Oita University, Oita, Japan.
Departments of Oral and Maxillofacial Surgery, Faculty of Medicine, Oita University, Oita, Japan.
Diagn Cytopathol. 2023 Jul;51(7):E224-E227. doi: 10.1002/dc.25139. Epub 2023 Apr 13.
Sialadenoma papilliferum, a benign and rare salivary gland neoplasm, accounts for 0.4%-1.2% of all salivary gland tumors and occurs primarily in minor salivary glands of the oral cavity. Here, we report a case of sialadenoma papilliferum and its associated cytological findings. A papillary tumor was incidentally detected on the palate of an 86-year-old Japanese man. Conventional oral exfoliative cytology was performed; the cytology smear exhibited epithelial clusters composed of atypical epithelial cells with a high nuclear/cytoplasm ratio and arranged in sheet or small papillary-like projections. Cytoplasmic vacuoles were also observed in the papillae. It was difficult to make a definitive diagnosis due to the presence of uncommon cytological features. The excisional biopsy specimen revealed histological features characteristic of sialadenoma papilliferum. Mutational analysis detected BRAFV600E mutation, which confirmed the diagnosis of sialadenoma papilliferum. To the best of our knowledge, no prior cytomorphological evaluations of sialadenoma papilliferum have been reported in detail. Oral exfoliative cytology specimens from salivary gland tumors can demonstrate uncommon cytomorphological features. A differential diagnosis of sialadenoma papilliferum can be based on the observation of mildly atypical epithelial cells that form small papillary-like structures.
乳头状涎腺瘤是一种良性且罕见的涎腺肿瘤，占所有涎腺肿瘤的 0.4%-1.2%，主要发生在口腔的小涎腺。本文报道了 1 例乳头状涎腺瘤及其相关细胞学表现。1 例 86 岁日本男性偶然发现腭部有一乳头状肿瘤。行常规口腔脱落细胞学检查；细胞学涂片显示上皮簇由具有高核/浆比的异型上皮细胞组成，呈片状或小乳头状突起排列。在乳头中还观察到细胞质空泡。由于存在不常见的细胞学特征，难以做出明确诊断。切除活检标本显示出具有乳头状涎腺瘤特征的组织学特征。突变分析检测到 BRAFV600E 突变，这证实了乳头状涎腺瘤的诊断。据我们所知，目前尚无关于乳头状涎腺瘤的详细细胞学评价。涎腺肿瘤的口腔脱落细胞学标本可表现出不常见的细胞学特征。乳头状涎腺瘤的鉴别诊断可以基于观察形成小乳头状样结构的轻度异型上皮细胞。
