Biggs J S, Hacker N, Andrews E, Munro C
Med J Aust. 1978 Nov 4;2(3 Suppl):23-5. doi: 10.5694/j.1326-5377.1978.tb77383.x.
Lactation occurs when the fully developed breast is released from the inhibitory influence which oestrogen and progesterone exert upon the action of prolactin. The use of oestrogens to suppress lactation depends on a continuation of the peripheral, that is, mammary, inhibition of prolactin. Androgens are also believed to act by inhibition of the action of prolactin on the mammary gland epithelium. Bromocriptine, when compared in a double-blind trial with orally administered methyl testosterone and placebo, gave almost complete relief of breast discomfort and congestion, though a small amount of milk production was seen. Methyl testosterone, in the dosage used in this study, was quite ineffective in suppressing lactation or breast symptoms.
当发育成熟的乳房从雌激素和孕酮对催乳素作用的抑制性影响中释放出来时，泌乳就会发生。使用雌激素抑制泌乳依赖于外周（即乳腺）对催乳素的持续抑制作用。雄激素也被认为是通过抑制催乳素对乳腺上皮的作用来发挥作用的。在一项双盲试验中，将溴隐亭与口服甲基睾酮和安慰剂进行比较，结果显示溴隐亭几乎能完全缓解乳房不适和胀痛，不过仍有少量乳汁分泌。在本研究中所使用的剂量下，甲基睾酮在抑制泌乳或乳房症状方面相当无效。
