Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Adv Exp Med Biol. 2023;1402:135-143. doi: 10.1007/978-3-031-25588-5_10.
The failure of cartilage healing is a major impediment to recovery from joint disease or trauma. Growth factors play a central role in cell function and have been proposed as potential therapeutic agents to promote cartilage repair. Decades of investigation have identified many growth factors that promote the formation of cartilage in vitro and in vivo. However, very few of these have progressed to human trials. A growth factor that robustly augments articular cartilage healing remains elusive. This is not surprising. Articular cartilage repair involves multiple cellular processes and it is unlikely that any single agent will be able to optimally regulate all of them. It is more likely that multiple regulatory molecules may be required to optimize the maintenance and restoration of articular cartilage. If this is the case, then interactions among growth factors may be expected to play a key role in determining their therapeutic value. This review explores the hypothesis that growth factor interactions could help optimize articular cartilage healing.
软骨愈合失败是关节疾病或创伤恢复的主要障碍。生长因子在细胞功能中起着核心作用，并被提议作为潜在的治疗剂来促进软骨修复。数十年来的研究已经确定了许多促进体外和体内软骨形成的生长因子。然而，其中很少有进展到人体试验。一种能够强烈增强关节软骨愈合的生长因子仍然难以捉摸。这并不奇怪。关节软骨修复涉及多种细胞过程，不太可能有任何单一的药物能够最佳地调节所有这些过程。更有可能的是，可能需要多种调节分子来优化关节软骨的维持和恢复。如果是这样，那么生长因子之间的相互作用可能在决定其治疗价值方面发挥关键作用。本综述探讨了这样一种假设，即生长因子相互作用可以帮助优化关节软骨愈合。
