Trippel S, Cucchiarini M, Madry H, Shi S, Wang C
Department of Orthopaedic Surgery, Indiana University School of Medicine, 541 Clinical Drive, Suite 600, Indianapolis, IP 46202-5111, USA.
Proc Inst Mech Eng H. 2007 Jul;221(5):451-9. doi: 10.1243/09544119JEIM237.
Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells' degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor I, fibroblast growth factor 2, bone morphogenetic proteins 2, 4, and 7, and interleukin-1 receptor antagonist. It is now possible to transfer the genes encoding such molecules into articular cartilage and synovial lining cells. Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage.
关节软骨作为关节的滑动表面。它易受创伤和退行性疾病的损害。通过使用增强细胞修复活性、抑制细胞降解活性或兼具两者功能的细胞调节分子，有可能实现受损关节软骨的修复。已鉴定出多种此类分子。这些分子包括胰岛素样生长因子I、成纤维细胞生长因子2、骨形态发生蛋白2、4和7，以及白细胞介素-1受体拮抗剂。现在可以将编码此类分子的基因转移到关节软骨和滑膜衬里细胞中。尽管尚处于初步阶段，但体外和体内研究的数据表明，基因治疗可以递送这些潜在的治疗剂，以保护现有的软骨并生成新的软骨。
