小于 34 孕周早产儿生后甲状腺激素及甲状腺功能障碍的发育趋势。
Developmental Trends in Postnatal Thyroid Hormones and Thyroid Dysfunction in Preterm Infants Born at less than 34 weeks Gestation.
机构信息
Medical College of Nanchang University, Nanchang, Jiangxi, China.
Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
出版信息
Fetal Pediatr Pathol. 2023 Aug;42(4):619-629. doi: 10.1080/15513815.2023.2195520. Epub 2023 Apr 13.
OBJECTIVES
To analyse the trends in thyroid function tests (TFT) in preterm infants, evaluate the frequency of thyroid dysfunction, and identify the factors that influence thyroid function.
METHODS
The TFT results and risk factors for thyroid dysfunction in preterm infants with gestational ages (GA) between 25 and 34 weeks were analysed.
RESULTS
In total, 535 infants were enrolled in this study. Thyroid hormone levels vary with gestational and postnatal age, and the total frequency of thyroid dysfunction is 50.3%. Thirty-one infants (5.8%) had delayed TSH elevation. Transient hypothyroxinaemia of prematurity remained significantly associated with both lower birth weight and GA. Congenital hypothyroidism was significantly associated with lower birth weight, 5 min Apgar score, and dopamine use.
CONCLUSIONS
Thyroid hormone levels in preterm infants are related to gestation and postnatal age, the frequency of thyroid dysfunction in premature infants is high, and is negatively correlated with GA and birth weight.
目的
分析早产儿甲状腺功能检查（TFT）的变化趋势，评估甲状腺功能障碍的发生率，并确定影响甲状腺功能的因素。
方法
分析胎龄（GA）为 25-34 周的早产儿的 TFT 结果及甲状腺功能障碍的危险因素。
结果
共纳入 535 例婴儿。甲状腺激素水平随胎龄和出生后年龄而变化，甲状腺功能障碍的总发生率为 50.3%。31 例（5.8%）出现 TSH 延迟升高。早产儿暂时性甲状腺功能减退症与出生体重和 GA 均显著相关。先天性甲状腺功能减退症与出生体重、5 分钟 Apgar 评分和多巴胺使用显著相关。
结论
早产儿甲状腺激素水平与胎龄和出生后年龄有关，早产儿甲状腺功能障碍的发生率较高，与 GA 和出生体重呈负相关。
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